Epidemiological study on Korean gallstone disease

A nationwide cooperative study

Myung Hwan Kim, Byeong Cheol Lim, Seung Jae Myung, Sung Koo Lee, Hee Cheul Ohrr, Yong Tae Kim, Im Hwan Roe, Jin Hong Kim, Jae Bock Chung, Chang Duck Kim, Chan Sup Shim, Yong Bum Yun, Young Il Min, Ung Suk Yang, Jin Kyung Kang

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

To clarify the epidemiological characteristics of gallstone disease in Korea and to evaluate the chronological changes in gallstone disease, the authors performed this first prospective nationwide cooperative study. The subjects were 1263 gallstone patients who were admitted at 19 hospitals in Korea from February to July 1997. Questionnaires were recorded on 1263 patients and gallstones were harvested from 1133 patients. The proportion of patients with gallbladder (GB), common bile duct (CBD), and intrahepatic duct (IHD) stones among total gallstone patients was 64.0%, 21.9%, and 14.1%, respectively. GB stones were categorized as cholesterol (58.1%), black pigment (25.2%), and brown pigment (12.1%) stones. CBD stones were classified as brown pigment (76.1%), cholesterol (18.4%), and black pigment (3.5%) stones. IHD stones were classified as brown pigment (61.4%) and mixed (35.6%) stones. Intrahepatic mixed stones had mean cholesterol and bilirubin contents of 63.4 ± 20.8% and 23.1 ± 9.9%, respectively. In contrast, IHD brown pigment stones had mean cholesterol and bilirubin contents of 35.1 ± 20.5% and 39.6 ± 17.4%, respectively. Our study showed that the type and composition of gallstones in Korea was somewhat different compared with those in the West. This study also demonstrated that there have been chronological changes in the type and composition of gallstones when compared with previous domestic data. Another nationwide cooperative study may be needed to elucidate and confirm the changing pattern of gallstone disease.

Original languageEnglish
Pages (from-to)1674-1683
Number of pages10
JournalDigestive Diseases and Sciences
Volume44
Issue number8
DOIs
Publication statusPublished - 1999 Sep 24

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Gallstones
Epidemiologic Studies
Korea
Cholesterol
Common Bile Duct
Gallbladder
Bilirubin

Keywords

  • Epidemiology
  • Gallstone
  • Korea

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Kim, M. H., Lim, B. C., Myung, S. J., Lee, S. K., Ohrr, H. C., Kim, Y. T., ... Kang, J. K. (1999). Epidemiological study on Korean gallstone disease: A nationwide cooperative study. Digestive Diseases and Sciences, 44(8), 1674-1683. https://doi.org/10.1023/A:1026643817349

Epidemiological study on Korean gallstone disease : A nationwide cooperative study. / Kim, Myung Hwan; Lim, Byeong Cheol; Myung, Seung Jae; Lee, Sung Koo; Ohrr, Hee Cheul; Kim, Yong Tae; Roe, Im Hwan; Kim, Jin Hong; Chung, Jae Bock; Kim, Chang Duck; Shim, Chan Sup; Yun, Yong Bum; Min, Young Il; Yang, Ung Suk; Kang, Jin Kyung.

In: Digestive Diseases and Sciences, Vol. 44, No. 8, 24.09.1999, p. 1674-1683.

Research output: Contribution to journalArticle

Kim, MH, Lim, BC, Myung, SJ, Lee, SK, Ohrr, HC, Kim, YT, Roe, IH, Kim, JH, Chung, JB, Kim, CD, Shim, CS, Yun, YB, Min, YI, Yang, US & Kang, JK 1999, 'Epidemiological study on Korean gallstone disease: A nationwide cooperative study', Digestive Diseases and Sciences, vol. 44, no. 8, pp. 1674-1683. https://doi.org/10.1023/A:1026643817349
Kim, Myung Hwan ; Lim, Byeong Cheol ; Myung, Seung Jae ; Lee, Sung Koo ; Ohrr, Hee Cheul ; Kim, Yong Tae ; Roe, Im Hwan ; Kim, Jin Hong ; Chung, Jae Bock ; Kim, Chang Duck ; Shim, Chan Sup ; Yun, Yong Bum ; Min, Young Il ; Yang, Ung Suk ; Kang, Jin Kyung. / Epidemiological study on Korean gallstone disease : A nationwide cooperative study. In: Digestive Diseases and Sciences. 1999 ; Vol. 44, No. 8. pp. 1674-1683.
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abstract = "To clarify the epidemiological characteristics of gallstone disease in Korea and to evaluate the chronological changes in gallstone disease, the authors performed this first prospective nationwide cooperative study. The subjects were 1263 gallstone patients who were admitted at 19 hospitals in Korea from February to July 1997. Questionnaires were recorded on 1263 patients and gallstones were harvested from 1133 patients. The proportion of patients with gallbladder (GB), common bile duct (CBD), and intrahepatic duct (IHD) stones among total gallstone patients was 64.0{\%}, 21.9{\%}, and 14.1{\%}, respectively. GB stones were categorized as cholesterol (58.1{\%}), black pigment (25.2{\%}), and brown pigment (12.1{\%}) stones. CBD stones were classified as brown pigment (76.1{\%}), cholesterol (18.4{\%}), and black pigment (3.5{\%}) stones. IHD stones were classified as brown pigment (61.4{\%}) and mixed (35.6{\%}) stones. Intrahepatic mixed stones had mean cholesterol and bilirubin contents of 63.4 ± 20.8{\%} and 23.1 ± 9.9{\%}, respectively. In contrast, IHD brown pigment stones had mean cholesterol and bilirubin contents of 35.1 ± 20.5{\%} and 39.6 ± 17.4{\%}, respectively. Our study showed that the type and composition of gallstones in Korea was somewhat different compared with those in the West. This study also demonstrated that there have been chronological changes in the type and composition of gallstones when compared with previous domestic data. Another nationwide cooperative study may be needed to elucidate and confirm the changing pattern of gallstone disease.",
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AU - Roe, Im Hwan

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AU - Chung, Jae Bock

AU - Kim, Chang Duck

AU - Shim, Chan Sup

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N2 - To clarify the epidemiological characteristics of gallstone disease in Korea and to evaluate the chronological changes in gallstone disease, the authors performed this first prospective nationwide cooperative study. The subjects were 1263 gallstone patients who were admitted at 19 hospitals in Korea from February to July 1997. Questionnaires were recorded on 1263 patients and gallstones were harvested from 1133 patients. The proportion of patients with gallbladder (GB), common bile duct (CBD), and intrahepatic duct (IHD) stones among total gallstone patients was 64.0%, 21.9%, and 14.1%, respectively. GB stones were categorized as cholesterol (58.1%), black pigment (25.2%), and brown pigment (12.1%) stones. CBD stones were classified as brown pigment (76.1%), cholesterol (18.4%), and black pigment (3.5%) stones. IHD stones were classified as brown pigment (61.4%) and mixed (35.6%) stones. Intrahepatic mixed stones had mean cholesterol and bilirubin contents of 63.4 ± 20.8% and 23.1 ± 9.9%, respectively. In contrast, IHD brown pigment stones had mean cholesterol and bilirubin contents of 35.1 ± 20.5% and 39.6 ± 17.4%, respectively. Our study showed that the type and composition of gallstones in Korea was somewhat different compared with those in the West. This study also demonstrated that there have been chronological changes in the type and composition of gallstones when compared with previous domestic data. Another nationwide cooperative study may be needed to elucidate and confirm the changing pattern of gallstone disease.

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