Epidemiology and clinical features of toxigenic culture-confirmed hospital–onset Clostridium difficile infection

A multicentre prospective study in tertiary hospitals of South Korea

Sang Hoon Han, Heejung Kim, Kyungwon Lee, Su Jin Jeong, Ki Ho Park, Joon-Young Song, Yu Bin Seo, Jun Yong Choi, Jun Hee Woo, Woo Joo Kim, June Myung Kim

Research output: Contribution to journalArticle

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Abstract

Hypervirulent Clostridium difficile strains, most notably BI/NAP1/027, have been increasingly emerging in Western countries as local epidemics. We performed a prospective multicentre observational study from December 2011 to May 2012 to identify recent incidences of toxigenic culture-confirmed hospital-onset C. difficile infections (CDI) and their associated clinical characteristics in South Korea. Patients suspected of having been suffering from CDI more than 48 h after admission and aged ≥ 20 years were prospectively enrolled and provided loose stool specimens. Toxigenic C. difficile culture (anaerobic culture+toxin A/B/binary gene PCR) and PCR ribotyping were performed in one central laboratory. We enrolled 98 toxigenic cultureconfirmed CDI-infected patients and 250 toxigenic culture-negative participants from three hospitals. The incidence of toxigenic culture-confirmed hospital-onset CDI cases was 2.7 per 10 000 patient-days. The percentage of severe CDI cases was relatively low at only 3.1%. UK ribotype 018 was the predominant type (48.1%). There were no hypervirulent BI/NAP1/027 isolates identified. The independent risk factors for toxigenic culture-confirmed hospital-onset CDI were invasive procedure (odds ratio (OR) 7.3, P50.003) and past CDI history within 3 months (OR 28.5, P50.003). In conclusion, the incidence and severity of CDI in our study were not higher than reported in Western countries.

Original languageEnglish
Article number070672
Pages (from-to)1542-1551
Number of pages10
JournalJournal of Medical Microbiology
Volume63
DOIs
Publication statusPublished - 2014 Nov 1

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Clostridium Infections
Republic of Korea
Clostridium difficile
Tertiary Care Centers
Multicenter Studies
Epidemiology
Prospective Studies
Ribotyping
Incidence
Odds Ratio
Polymerase Chain Reaction
Observational Studies

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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Epidemiology and clinical features of toxigenic culture-confirmed hospital–onset Clostridium difficile infection : A multicentre prospective study in tertiary hospitals of South Korea. / Han, Sang Hoon; Kim, Heejung; Lee, Kyungwon; Jeong, Su Jin; Park, Ki Ho; Song, Joon-Young; Seo, Yu Bin; Choi, Jun Yong; Woo, Jun Hee; Kim, Woo Joo; Kim, June Myung.

In: Journal of Medical Microbiology, Vol. 63, 070672, 01.11.2014, p. 1542-1551.

Research output: Contribution to journalArticle

Han, Sang Hoon ; Kim, Heejung ; Lee, Kyungwon ; Jeong, Su Jin ; Park, Ki Ho ; Song, Joon-Young ; Seo, Yu Bin ; Choi, Jun Yong ; Woo, Jun Hee ; Kim, Woo Joo ; Kim, June Myung. / Epidemiology and clinical features of toxigenic culture-confirmed hospital–onset Clostridium difficile infection : A multicentre prospective study in tertiary hospitals of South Korea. In: Journal of Medical Microbiology. 2014 ; Vol. 63. pp. 1542-1551.
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