Epidemiology and trends in the antibiotic susceptibilities of Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region, 2010–2013

Ya Ting Chang, Geoffrey Coombs, Thomas Ling, V. Balaji, Camilla Rodrigues, Hiroshige Mikamo, Ja Kim Min, Datin Ganeswrie Rajasekaram, Myrna Mendoza, Thean Yen Tan, Pattarachai Kiratisin, Yuxing Ni, Weinman Barry, Yingchun Xu, Yen Hsu Chen, Po Ren Hsueh

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Abstract

This study was conducted to investigate the epidemiology and antimicrobial susceptibility patterns of Gram-negative bacilli (GNB) isolated from intra-abdominal infections (IAIs) in the Asia-Pacific region (APR) from 2010–2013. A total of 17 350 isolates were collected from 54 centres in 13 countries in the APR. The three most commonly isolated GNB were Escherichia coli (46.1%), Klebsiella pneumoniae (19.3%) and Pseudomonas aeruginosa (9.8%). Overall, the rates of extended-spectrum β-lactamase (ESBL)-producing E. coli and K. pneumoniae were 38.2% and 24.3%, respectively, and they were highest in China (66.6% and 38.7%, respectively), Thailand (49.8% and 36.5%, respectively) and Vietnam (47.9% and 30.4%, respectively). During 2010–2013, the rates of ESBL-producing E. coli and K. pneumoniae isolates causing community-associated (CA) IAIs (collected <48 h after admission) were 26.0% and 13.5%, respectively, and those causing hospital-associated (HA) IAIs were 48.0% and 30.6%, respectively. Amikacin, ertapenem and imipenem were the most effective agents against ESBL-producing isolates. Piperacillin/tazobactam displayed good in vitro activity (91.4%) against CA ESBL-producing E. coli. For other commonly isolated Enterobacteriaceae, fluoroquinolones, cefepime and carbapenems exhibited better in vitro activities than third-generation cephalosporins. Amikacin possessed high in vitro activity against all GNB isolates (>80%) causing IAIs, except for Acinetobacter calcoaceticus–baumannii (ACB) complex (30.9% for HA-IAI isolates). All of the antimicrobial agents tested exhibited <45% in vitro activity against ACB complex. Antimicrobial resistance is a persistent threat in the APR and continuous monitoring of evolutionary trends in the susceptibility patterns of GNB causing IAIs in this region is mandatory.

Original languageEnglish
Pages (from-to)734-739
Number of pages6
JournalInternational Journal of Antimicrobial Agents
Volume49
Issue number6
DOIs
Publication statusPublished - 2017 Jun 1

Fingerprint

Intraabdominal Infections
Bacillus
Epidemiology
Anti-Bacterial Agents
Klebsiella pneumoniae
Acinetobacter
Escherichia coli
Vietnam
Thailand
Anti-Infective Agents
Pseudomonas aeruginosa
China

Keywords

  • Antimicrobial susceptibility
  • Asia-Pacific region
  • Epidemiology
  • Extended-spectrum β-lactamase
  • Gram-negative bacilli
  • Intra-abdominal infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Epidemiology and trends in the antibiotic susceptibilities of Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region, 2010–2013. / Chang, Ya Ting; Coombs, Geoffrey; Ling, Thomas; Balaji, V.; Rodrigues, Camilla; Mikamo, Hiroshige; Min, Ja Kim; Rajasekaram, Datin Ganeswrie; Mendoza, Myrna; Tan, Thean Yen; Kiratisin, Pattarachai; Ni, Yuxing; Barry, Weinman; Xu, Yingchun; Chen, Yen Hsu; Hsueh, Po Ren.

In: International Journal of Antimicrobial Agents, Vol. 49, No. 6, 01.06.2017, p. 734-739.

Research output: Contribution to journalArticle

Chang, YT, Coombs, G, Ling, T, Balaji, V, Rodrigues, C, Mikamo, H, Min, JK, Rajasekaram, DG, Mendoza, M, Tan, TY, Kiratisin, P, Ni, Y, Barry, W, Xu, Y, Chen, YH & Hsueh, PR 2017, 'Epidemiology and trends in the antibiotic susceptibilities of Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region, 2010–2013', International Journal of Antimicrobial Agents, vol. 49, no. 6, pp. 734-739. https://doi.org/10.1016/j.ijantimicag.2017.01.030
Chang, Ya Ting ; Coombs, Geoffrey ; Ling, Thomas ; Balaji, V. ; Rodrigues, Camilla ; Mikamo, Hiroshige ; Min, Ja Kim ; Rajasekaram, Datin Ganeswrie ; Mendoza, Myrna ; Tan, Thean Yen ; Kiratisin, Pattarachai ; Ni, Yuxing ; Barry, Weinman ; Xu, Yingchun ; Chen, Yen Hsu ; Hsueh, Po Ren. / Epidemiology and trends in the antibiotic susceptibilities of Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region, 2010–2013. In: International Journal of Antimicrobial Agents. 2017 ; Vol. 49, No. 6. pp. 734-739.
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abstract = "This study was conducted to investigate the epidemiology and antimicrobial susceptibility patterns of Gram-negative bacilli (GNB) isolated from intra-abdominal infections (IAIs) in the Asia-Pacific region (APR) from 2010–2013. A total of 17 350 isolates were collected from 54 centres in 13 countries in the APR. The three most commonly isolated GNB were Escherichia coli (46.1{\%}), Klebsiella pneumoniae (19.3{\%}) and Pseudomonas aeruginosa (9.8{\%}). Overall, the rates of extended-spectrum β-lactamase (ESBL)-producing E. coli and K. pneumoniae were 38.2{\%} and 24.3{\%}, respectively, and they were highest in China (66.6{\%} and 38.7{\%}, respectively), Thailand (49.8{\%} and 36.5{\%}, respectively) and Vietnam (47.9{\%} and 30.4{\%}, respectively). During 2010–2013, the rates of ESBL-producing E. coli and K. pneumoniae isolates causing community-associated (CA) IAIs (collected <48 h after admission) were 26.0{\%} and 13.5{\%}, respectively, and those causing hospital-associated (HA) IAIs were 48.0{\%} and 30.6{\%}, respectively. Amikacin, ertapenem and imipenem were the most effective agents against ESBL-producing isolates. Piperacillin/tazobactam displayed good in vitro activity (91.4{\%}) against CA ESBL-producing E. coli. For other commonly isolated Enterobacteriaceae, fluoroquinolones, cefepime and carbapenems exhibited better in vitro activities than third-generation cephalosporins. Amikacin possessed high in vitro activity against all GNB isolates (>80{\%}) causing IAIs, except for Acinetobacter calcoaceticus–baumannii (ACB) complex (30.9{\%} for HA-IAI isolates). All of the antimicrobial agents tested exhibited <45{\%} in vitro activity against ACB complex. Antimicrobial resistance is a persistent threat in the APR and continuous monitoring of evolutionary trends in the susceptibility patterns of GNB causing IAIs in this region is mandatory.",
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T1 - Epidemiology and trends in the antibiotic susceptibilities of Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region, 2010–2013

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AU - Coombs, Geoffrey

AU - Ling, Thomas

AU - Balaji, V.

AU - Rodrigues, Camilla

AU - Mikamo, Hiroshige

AU - Min, Ja Kim

AU - Rajasekaram, Datin Ganeswrie

AU - Mendoza, Myrna

AU - Tan, Thean Yen

AU - Kiratisin, Pattarachai

AU - Ni, Yuxing

AU - Barry, Weinman

AU - Xu, Yingchun

AU - Chen, Yen Hsu

AU - Hsueh, Po Ren

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N2 - This study was conducted to investigate the epidemiology and antimicrobial susceptibility patterns of Gram-negative bacilli (GNB) isolated from intra-abdominal infections (IAIs) in the Asia-Pacific region (APR) from 2010–2013. A total of 17 350 isolates were collected from 54 centres in 13 countries in the APR. The three most commonly isolated GNB were Escherichia coli (46.1%), Klebsiella pneumoniae (19.3%) and Pseudomonas aeruginosa (9.8%). Overall, the rates of extended-spectrum β-lactamase (ESBL)-producing E. coli and K. pneumoniae were 38.2% and 24.3%, respectively, and they were highest in China (66.6% and 38.7%, respectively), Thailand (49.8% and 36.5%, respectively) and Vietnam (47.9% and 30.4%, respectively). During 2010–2013, the rates of ESBL-producing E. coli and K. pneumoniae isolates causing community-associated (CA) IAIs (collected <48 h after admission) were 26.0% and 13.5%, respectively, and those causing hospital-associated (HA) IAIs were 48.0% and 30.6%, respectively. Amikacin, ertapenem and imipenem were the most effective agents against ESBL-producing isolates. Piperacillin/tazobactam displayed good in vitro activity (91.4%) against CA ESBL-producing E. coli. For other commonly isolated Enterobacteriaceae, fluoroquinolones, cefepime and carbapenems exhibited better in vitro activities than third-generation cephalosporins. Amikacin possessed high in vitro activity against all GNB isolates (>80%) causing IAIs, except for Acinetobacter calcoaceticus–baumannii (ACB) complex (30.9% for HA-IAI isolates). All of the antimicrobial agents tested exhibited <45% in vitro activity against ACB complex. Antimicrobial resistance is a persistent threat in the APR and continuous monitoring of evolutionary trends in the susceptibility patterns of GNB causing IAIs in this region is mandatory.

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