Epidural adhesiolysis complicated by cefazolin-induced status epilepticus: Two cases

Jeong Yoon Choi, Hung Youl Seok, Sang Heon Lee, Byung Jo Kim, Kun Woo Park, Ki Young Jung

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Cefazolin is a strong epileptogenic agent. We describe two patients presenting with status epilepticus, apparently caused by intrathecal leakage of cefazolin via incidental dural puncture during spinal epidural adhesiolysis. Our cases suggest that the local use of antibiotics, particularly cefazolin, in the form of a mixture with contrast medium during a spinal procedure is not advisable, because of the possible incidental intrathecal leakage and the high convulsive potential of the antibiotics.

Original languageEnglish
Pages (from-to)1041-1043
Number of pages3
JournalClinical Neurology and Neurosurgery
Issue number10
Publication statusPublished - 2008 Dec


  • Adverse effects
  • Cefazolin
  • Intrathecal injection
  • Status epilepticus

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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