Epidural sufentanil provides better analgesia from 24 h after surgery compared with epidural fentanyl in children

Jang-Eun Cho, J. Y. Kim, J. E. Kim, D. H. Chun, N. H. Jun, H. K. Kil

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Studies comparing epidural fentanyl and sufentanil in adults reported a similar analgesic effect with variable side effects. We hypothesized that epidural fentanyl and sufentanil will have a similar analgesic effect in children undergoing urological surgery. Methods: Sixty-four children undergoing urological surgery were randomized into two groups: fentanyl in ropivacaine (fentanyl group, n=32) and sufentanil in ropivacaine (sufentanil group, n=32). After anaesthesia, an epidural catheter was inserted at the L2-3, L3-4 or L4-5 interspace. For post-operative pain relief, a solution consisting of fentanyl 0.1 mcg/kg/ml or sufentanil 0.015 mcg/kg/ml in 1.5 mg/ml ropivacaine was infused at a rate of 2 ml/h. To assess post-operative pain, the faces pain scale and the face, legs, activity, cry, consolability score were recorded at 1, 6, 24, 48 and 72 h after surgery. The incidence of adverse effects such as hypoxia, sedation, pruritus, nausea and/or vomiting was also evaluated. Results: Pain scores demonstrated no significant difference between the groups. The need for rescue analgesia during 24-72 h was higher in the fentanyl group than in the sufentanil group (6/32 vs. 0/32, P=0.012). The incidence of pruritus was higher in the sufentanil group compared with that in the fentanyl group (5/32 vs. 0/32). Conclusions: Epidural sufentanil provides better analgesia from 24 h after surgery compared with epidural fentanyl in infants and children undergoing urological surgery. The incidence of pruritus in the sufentanil group was higher than that in the fentanyl group.

Original languageEnglish
Pages (from-to)1360-1363
Number of pages4
JournalActa Anaesthesiologica Scandinavica
Volume52
Issue number10
DOIs
Publication statusPublished - 2008 Nov 1
Externally publishedYes

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Sufentanil
Fentanyl
Analgesia
Pruritus
Pain
Analgesics
Incidence
Facial Pain
Nausea
Vomiting
Leg
Catheters
Anesthesia

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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Epidural sufentanil provides better analgesia from 24 h after surgery compared with epidural fentanyl in children. / Cho, Jang-Eun; Kim, J. Y.; Kim, J. E.; Chun, D. H.; Jun, N. H.; Kil, H. K.

In: Acta Anaesthesiologica Scandinavica, Vol. 52, No. 10, 01.11.2008, p. 1360-1363.

Research output: Contribution to journalArticle

Cho, Jang-Eun ; Kim, J. Y. ; Kim, J. E. ; Chun, D. H. ; Jun, N. H. ; Kil, H. K. / Epidural sufentanil provides better analgesia from 24 h after surgery compared with epidural fentanyl in children. In: Acta Anaesthesiologica Scandinavica. 2008 ; Vol. 52, No. 10. pp. 1360-1363.
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AU - Kim, J. Y.

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AU - Jun, N. H.

AU - Kil, H. K.

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AB - Background: Studies comparing epidural fentanyl and sufentanil in adults reported a similar analgesic effect with variable side effects. We hypothesized that epidural fentanyl and sufentanil will have a similar analgesic effect in children undergoing urological surgery. Methods: Sixty-four children undergoing urological surgery were randomized into two groups: fentanyl in ropivacaine (fentanyl group, n=32) and sufentanil in ropivacaine (sufentanil group, n=32). After anaesthesia, an epidural catheter was inserted at the L2-3, L3-4 or L4-5 interspace. For post-operative pain relief, a solution consisting of fentanyl 0.1 mcg/kg/ml or sufentanil 0.015 mcg/kg/ml in 1.5 mg/ml ropivacaine was infused at a rate of 2 ml/h. To assess post-operative pain, the faces pain scale and the face, legs, activity, cry, consolability score were recorded at 1, 6, 24, 48 and 72 h after surgery. The incidence of adverse effects such as hypoxia, sedation, pruritus, nausea and/or vomiting was also evaluated. Results: Pain scores demonstrated no significant difference between the groups. The need for rescue analgesia during 24-72 h was higher in the fentanyl group than in the sufentanil group (6/32 vs. 0/32, P=0.012). The incidence of pruritus was higher in the sufentanil group compared with that in the fentanyl group (5/32 vs. 0/32). Conclusions: Epidural sufentanil provides better analgesia from 24 h after surgery compared with epidural fentanyl in infants and children undergoing urological surgery. The incidence of pruritus in the sufentanil group was higher than that in the fentanyl group.

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