Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination

Heung Kang Tae, Hyup Lee Jin, Kil Song Chung, Dong Han Hee, Cheol Shin Byung, Sara I. Pai, Chien Fu Hung, Cornelia Trimble, Jong Seok Lim, Tae Woo Kim, T. C. Wu

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Immunotherapy and chemotherapy are generally effective against small tumors in animal models of cancer. However, these treatment regimens are generally ineffective against large, bulky tumors. We have found that a multimodality treatment regimen using DNA vaccination in combination with chemotherapeutic agent epigallocatechin-3-gallate (EGCG), a compound found in green tea, is effective in inhibiting large tumor growth. EGCG was found to induce tumor cellular apoptosis in a dose-dependent manner. The combination of EGCG and DNA vaccination led to an enhanced tumor-specific T-cell immune response and enhanced antitumor effects, resulting in a higher cure rate than either immunotherapy or EGCG alone. In addition, combined DNA vaccination and oral EGCG treatment provided long-term antitumor protection in cured mice. Cured animals rejected a challenge of E7-expressing tumors, such as TC-1 and B16E7, but not a challenge of B16 7 weeks after the combined treatment, showing antigen-specific immune responses. These results suggest that multimodality treatment strategies, such as combining immunotherapy with a tumor-killing cancer drug, may be a more effective anticancer strategy than single-modality treatments.

Original languageEnglish
Pages (from-to)802-811
Number of pages10
JournalCancer Research
Volume67
Issue number2
DOIs
Publication statusPublished - 2007 Jan 15

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Epigallocatechin-3-gallate enhances CD8<sup>+</sup> T cell-mediated antitumor immunity induced by DNA vaccination'. Together they form a unique fingerprint.

  • Cite this

    Tae, H. K., Jin, H. L., Chung, K. S., Hee, D. H., Byung, C. S., Pai, S. I., Hung, C. F., Trimble, C., Lim, J. S., Kim, T. W., & Wu, T. C. (2007). Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination. Cancer Research, 67(2), 802-811. https://doi.org/10.1158/0008-5472.CAN-06-2638