Epigenetic regulation of axon regeneration after neural injury

Jung Eun Shin, Yongcheol Cho

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

When peripheral axons are damaged, neuronal injury signaling pathways induce transcriptional changes that support axon regeneration and consequent functional recovery. The recent development of bioinformatics techniques has allowed for the identification of many of the regeneration-associated genes that are regulated by neural injury, yet it remains unclear how global changes in transcriptome are coordinated. In this article, we review recent studies on the epigenetic mechanisms orchestrating changes in gene expression in response to nerve injury. We highlight the importance of epigenetic mechanisms in discriminating efficient axon regeneration in the peripheral nervous system and very limited axon regrowth in the central nervous system and discuss the therapeutic potential of targeting epigenetic regulators to improve neural recovery.

Original languageEnglish
Pages (from-to)10-16
Number of pages7
JournalMolecules and cells
Volume40
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

Keywords

  • Axon regeneration
  • Epigenetic regulation
  • Histone modification
  • Nerve injury

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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