Epistatic interactions between CREB and CREM variants in affective disorder

Alberto Chiesa, Agnese Marsano, Changsu Han, Soo Jung Lee, Ashwin A. Patkar, Chi Un Pae, Alessandro Serretti

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of the present work is to investigate the existence of epistatic interactions possibly influencing psychotropic agents' response between rs6740584 within Cyclic adenosine monophosphate Response Element Binding (CREB) and rs12775799 within cAMP response element-modulator (CREM) variants in bipolar disorder (BD) and major depressive disorder (MDD). All BD and MDD patients were administered with the Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HAMD) at baseline and at endpoint, respectively. A multiple regression model was employed to investigate the existence of possible epistatic interactions between the two variants and diverse clinical factors including drug response in affective disorders. No significant epistatic interaction was observed between rs6740584 within CREB and rs12775799 within CREM on both symptom improvement and other clinical factors in affective disorders. Our preliminary results suggest that no epistatic interaction between rs6740584 within CREB and rs12775799 within CREM should exist on clinical improvement and clinical factors in affective disorders.

Original languageEnglish
Pages (from-to)200-203
Number of pages4
JournalPsychiatry Investigation
Volume11
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

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Response Elements
Mood Disorders
Cyclic AMP
Bipolar Disorder
Major Depressive Disorder
Depression
Pharmaceutical Preparations

Keywords

  • CREB
  • CREM
  • Epistasis
  • Response affective disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Chiesa, A., Marsano, A., Han, C., Lee, S. J., Patkar, A. A., Pae, C. U., & Serretti, A. (2014). Epistatic interactions between CREB and CREM variants in affective disorder. Psychiatry Investigation, 11(2), 200-203. https://doi.org/10.4306/pi.2014.11.2.200

Epistatic interactions between CREB and CREM variants in affective disorder. / Chiesa, Alberto; Marsano, Agnese; Han, Changsu; Lee, Soo Jung; Patkar, Ashwin A.; Pae, Chi Un; Serretti, Alessandro.

In: Psychiatry Investigation, Vol. 11, No. 2, 01.01.2014, p. 200-203.

Research output: Contribution to journalArticle

Chiesa, A, Marsano, A, Han, C, Lee, SJ, Patkar, AA, Pae, CU & Serretti, A 2014, 'Epistatic interactions between CREB and CREM variants in affective disorder', Psychiatry Investigation, vol. 11, no. 2, pp. 200-203. https://doi.org/10.4306/pi.2014.11.2.200
Chiesa, Alberto ; Marsano, Agnese ; Han, Changsu ; Lee, Soo Jung ; Patkar, Ashwin A. ; Pae, Chi Un ; Serretti, Alessandro. / Epistatic interactions between CREB and CREM variants in affective disorder. In: Psychiatry Investigation. 2014 ; Vol. 11, No. 2. pp. 200-203.
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