Eradication Rates of Helicobacter pylori in Korea Over the Past 10 years and Correlation of the Amount of Antibiotics Use: Nationwide Survey

Woon Geon Shin, Sang Woo Lee, Gwang Ho Baik, Kyu Chan Huh, Sang In Lee, Jun Won Chung, Woon Tae Jung, Moo In Park, Hye Kyung Jung, Heung Up Kim, Jeong Hwan Kim, Sang Young Seol, Soon Man Yoon, Seong Woo Jeon, Su Jin Hong, Gwang Ha Kim, Dong Ho Lee, Hyun Soo Kim, Suck Chei Choi, Hee Mo KangJoongyub Lee, Jae Gyu Kim, Jae J. Kim

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: The efficacy of proton-pump inhibitor–amoxicillin–clarithromycin therapy for H. pylori eradication has decreased over time. Objective: We assessed the trend of H. pylori eradication rates over the last 10 years and the relationship between the eradication rates and the amount of macrolide antibiotic use in a country with a high prevalence of H. pylori infection. Methods: This vast nationwide multicenter study was conducted with 34,139 adults treated for H. pylori infection from January 2001 to December 2010. The defined daily dose per km2 (DSD) of macrolide antibiotics was calculated (n = 141,019) using the Health Insurance Review & Assessment data base from 2008 to 2010 in the two cities which had the lowest (Jeju city) or highest (Chuncheon city) eradication rate. Results: The eradication rates of proton-pump inhibitor–amoxicillin–clarithromycin therapy ranged 84.9–87.5% from 2001 to 2007, and those of 2008 to 2010 ranged 80.0–81.4% with a decreasing trend (p < 0.0001). The decreasing trend of eradication rates for the overall first-line therapy was observed only in three of the seven geographic areas in Korea (p < 0.0001). The DSD of macrolide antibiotics was significantly higher in Jeju than Cheunchon city (0.85 vs 0.52, p < 0.0001). Conclusions: H. pylori eradication rates with clarithromycin-containing triple therapy in Korea showed a decreasing trend over the past 10 years, although the trend varied among geographic areas. This difference may be associated with the amount of macrolide antibiotic use.

Original languageEnglish
Pages (from-to)266-278
Number of pages13
JournalHelicobacter
Volume21
Issue number4
DOIs
Publication statusPublished - 2016 Aug 1

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Korea
Helicobacter pylori
Macrolides
Anti-Bacterial Agents
Proton Pumps
Helicobacter Infections
Clarithromycin
Population Growth
Therapeutics
Health Insurance
Multicenter Studies
Surveys and Questionnaires
Databases

Keywords

  • antibiotics
  • Helicobacter pylori
  • treatment failure
  • trends

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases

Cite this

Eradication Rates of Helicobacter pylori in Korea Over the Past 10 years and Correlation of the Amount of Antibiotics Use : Nationwide Survey. / Shin, Woon Geon; Lee, Sang Woo; Baik, Gwang Ho; Huh, Kyu Chan; Lee, Sang In; Chung, Jun Won; Jung, Woon Tae; Park, Moo In; Jung, Hye Kyung; Kim, Heung Up; Kim, Jeong Hwan; Seol, Sang Young; Yoon, Soon Man; Jeon, Seong Woo; Hong, Su Jin; Kim, Gwang Ha; Lee, Dong Ho; Kim, Hyun Soo; Choi, Suck Chei; Kang, Hee Mo; Lee, Joongyub; Kim, Jae Gyu; Kim, Jae J.

In: Helicobacter, Vol. 21, No. 4, 01.08.2016, p. 266-278.

Research output: Contribution to journalArticle

Shin, WG, Lee, SW, Baik, GH, Huh, KC, Lee, SI, Chung, JW, Jung, WT, Park, MI, Jung, HK, Kim, HU, Kim, JH, Seol, SY, Yoon, SM, Jeon, SW, Hong, SJ, Kim, GH, Lee, DH, Kim, HS, Choi, SC, Kang, HM, Lee, J, Kim, JG & Kim, JJ 2016, 'Eradication Rates of Helicobacter pylori in Korea Over the Past 10 years and Correlation of the Amount of Antibiotics Use: Nationwide Survey', Helicobacter, vol. 21, no. 4, pp. 266-278. https://doi.org/10.1111/hel.12279
Shin, Woon Geon ; Lee, Sang Woo ; Baik, Gwang Ho ; Huh, Kyu Chan ; Lee, Sang In ; Chung, Jun Won ; Jung, Woon Tae ; Park, Moo In ; Jung, Hye Kyung ; Kim, Heung Up ; Kim, Jeong Hwan ; Seol, Sang Young ; Yoon, Soon Man ; Jeon, Seong Woo ; Hong, Su Jin ; Kim, Gwang Ha ; Lee, Dong Ho ; Kim, Hyun Soo ; Choi, Suck Chei ; Kang, Hee Mo ; Lee, Joongyub ; Kim, Jae Gyu ; Kim, Jae J. / Eradication Rates of Helicobacter pylori in Korea Over the Past 10 years and Correlation of the Amount of Antibiotics Use : Nationwide Survey. In: Helicobacter. 2016 ; Vol. 21, No. 4. pp. 266-278.
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