ERDR1 enhances human NK cell cytotoxicity through an actin-regulated degranulation-dependent pathway

Ha Reum Lee; Scarlett Yoona Huh; Dae Young Hur; Hyuk Jeong; Tae Sung Kim; Sang Yoon Kim; Seung Beom Park; Yoolhee Yang; Sa Ik Bang; Hyunjeong Park; Daeho Cho

doi:10.1016/j.cellimm.2014.10.002

ERDR1 enhances human NK cell cytotoxicity through an actin-regulated degranulation-dependent pathway

Ha Reum Lee, Scarlett Yoona Huh, Dae Young Hur, Hyuk Jeong, Tae Sung Kim, Sang Yoon Kim, Seung Beom Park, Yoolhee Yang, Sa Ik Bang, Hyunjeong Park, Daeho Cho

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Erythroid differentiation regulator 1 (ERDR1), which is a stress-related survival factor, exhibits anti-cancer effects against melanoma. However, the function of ERDR1 on immune cells has not been examined. We investigated whether ERDR1 regulates the cytotoxic ability of human natural killer (NK) cells, which are known as innate effector lymphocytes. In this study, treatment with recombinant ERDR1 resulted in enhanced NK cell cytotoxicity through the secretion of lytic granules. Furthermore, actin modulation was involved in the ERDR1-enhanced NK cell cytotoxicity. ERDR1 stimulated actin accumulation at the immunological synapse, which was induced by the activation of Vav-1 in NK cells. These findings suggest new insight into the function of ERDR1 function in the human immune system.

Original language	English
Pages (from-to)	78-84
Number of pages	7
Journal	Cellular Immunology
Volume	292
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cellimm.2014.10.002
Publication status	Published - 2014 Nov 1

Keywords

Actin
Cytotoxicity
Erythroid differentiation regulator 1
Immune system
Natural killer cell

ASJC Scopus subject areas

Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cellimm.2014.10.002

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title = "ERDR1 enhances human NK cell cytotoxicity through an actin-regulated degranulation-dependent pathway",

abstract = "Erythroid differentiation regulator 1 (ERDR1), which is a stress-related survival factor, exhibits anti-cancer effects against melanoma. However, the function of ERDR1 on immune cells has not been examined. We investigated whether ERDR1 regulates the cytotoxic ability of human natural killer (NK) cells, which are known as innate effector lymphocytes. In this study, treatment with recombinant ERDR1 resulted in enhanced NK cell cytotoxicity through the secretion of lytic granules. Furthermore, actin modulation was involved in the ERDR1-enhanced NK cell cytotoxicity. ERDR1 stimulated actin accumulation at the immunological synapse, which was induced by the activation of Vav-1 in NK cells. These findings suggest new insight into the function of ERDR1 function in the human immune system.",

keywords = "Actin, Cytotoxicity, Erythroid differentiation regulator 1, Immune system, Natural killer cell",

author = "Lee, {Ha Reum} and Huh, {Scarlett Yoona} and Hur, {Dae Young} and Hyuk Jeong and Kim, {Tae Sung} and Kim, {Sang Yoon} and Park, {Seung Beom} and Yoolhee Yang and Bang, {Sa Ik} and Hyunjeong Park and Daeho Cho",

note = "Funding Information: This work was supported by Basic Science Research program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2012R1A2A2A02046972) and Korea Drug Development Fund (KDDF) funded by Ministry of Science, ICT and Future Planning, Ministry of Trade, Industry & Energy and Ministry of Health & Welfare (KDDF-201404-04, Republic of Korea). Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2014",

month = nov,

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doi = "10.1016/j.cellimm.2014.10.002",

language = "English",

volume = "292",

pages = "78--84",

journal = "Cellular Immunology",

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T1 - ERDR1 enhances human NK cell cytotoxicity through an actin-regulated degranulation-dependent pathway

AU - Lee, Ha Reum

AU - Huh, Scarlett Yoona

AU - Hur, Dae Young

AU - Jeong, Hyuk

AU - Kim, Tae Sung

AU - Kim, Sang Yoon

AU - Park, Seung Beom

AU - Yang, Yoolhee

AU - Bang, Sa Ik

AU - Park, Hyunjeong

AU - Cho, Daeho

N1 - Funding Information: This work was supported by Basic Science Research program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2012R1A2A2A02046972) and Korea Drug Development Fund (KDDF) funded by Ministry of Science, ICT and Future Planning, Ministry of Trade, Industry & Energy and Ministry of Health & Welfare (KDDF-201404-04, Republic of Korea). Publisher Copyright: © 2014 Elsevier Inc.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Erythroid differentiation regulator 1 (ERDR1), which is a stress-related survival factor, exhibits anti-cancer effects against melanoma. However, the function of ERDR1 on immune cells has not been examined. We investigated whether ERDR1 regulates the cytotoxic ability of human natural killer (NK) cells, which are known as innate effector lymphocytes. In this study, treatment with recombinant ERDR1 resulted in enhanced NK cell cytotoxicity through the secretion of lytic granules. Furthermore, actin modulation was involved in the ERDR1-enhanced NK cell cytotoxicity. ERDR1 stimulated actin accumulation at the immunological synapse, which was induced by the activation of Vav-1 in NK cells. These findings suggest new insight into the function of ERDR1 function in the human immune system.

AB - Erythroid differentiation regulator 1 (ERDR1), which is a stress-related survival factor, exhibits anti-cancer effects against melanoma. However, the function of ERDR1 on immune cells has not been examined. We investigated whether ERDR1 regulates the cytotoxic ability of human natural killer (NK) cells, which are known as innate effector lymphocytes. In this study, treatment with recombinant ERDR1 resulted in enhanced NK cell cytotoxicity through the secretion of lytic granules. Furthermore, actin modulation was involved in the ERDR1-enhanced NK cell cytotoxicity. ERDR1 stimulated actin accumulation at the immunological synapse, which was induced by the activation of Vav-1 in NK cells. These findings suggest new insight into the function of ERDR1 function in the human immune system.

KW - Actin

KW - Cytotoxicity

KW - Erythroid differentiation regulator 1

KW - Immune system

KW - Natural killer cell

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ER -

ERDR1 enhances human NK cell cytotoxicity through an actin-regulated degranulation-dependent pathway

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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