ERDR1 enhances human NK cell cytotoxicity through an actin-regulated degranulation-dependent pathway

Ha Reum Lee, Scarlett Yoona Huh, Dae Young Hur, Hyuk Jeong, Tae Sung Kim, Sang Yoon Kim, Seung Beom Park, Yoolhee Yang, Sa Ik Bang, Hyunjeong Park, Dae Ho Cho

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Erythroid differentiation regulator 1 (ERDR1), which is a stress-related survival factor, exhibits anti-cancer effects against melanoma. However, the function of ERDR1 on immune cells has not been examined. We investigated whether ERDR1 regulates the cytotoxic ability of human natural killer (NK) cells, which are known as innate effector lymphocytes. In this study, treatment with recombinant ERDR1 resulted in enhanced NK cell cytotoxicity through the secretion of lytic granules. Furthermore, actin modulation was involved in the ERDR1-enhanced NK cell cytotoxicity. ERDR1 stimulated actin accumulation at the immunological synapse, which was induced by the activation of Vav-1 in NK cells. These findings suggest new insight into the function of ERDR1 function in the human immune system.

Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalCellular Immunology
Volume292
Issue number1-2
DOIs
Publication statusPublished - 2014 Nov 1

ASJC Scopus subject areas

  • Immunology

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