■ BACKGROUND AND OBJECTIVE: To study characteristics of errors in thickness comparison maps (TCMs) from three-dimensional optical coherence tomography. ■ PATIENTS AND METHODS: Patients who underwent three-dimensional optical coherence tomography examinations were included. Errors in TCM were categorized into several types according to common features, and the origins and distributions of errors were investigated. ■ RESULTS: Errors were observed in 25 (22.9%) of 109 TCMs with a normal macula and in 88 (63.3%) of 139 TCMs with an abnormal macula (P < .001). The errors were categorized into three types: horizontal line-shaped errors that originated from fixation loss by the examinee, jumping errors caused by segmentation error, and two-peaked errors due to mismatching. There were significant differences in the distributions of the error types among different diagnoses. ■ CONCLUSION: Errors in TCM were categorized into several types according to common features. Distributions of these types differed among eyes according to diagnosis.
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