Erythroid differentiation regulator 1 ameliorates collagen-induced arthritis via activation of regulatory t cells

Myun Soo Kim, Sora Lee, Sunyoung Park, Kyung Eun Kim, Hyun Jeong Park, Daeho Cho

Research output: Contribution to journalArticlepeer-review

Abstract

Erythroid differentiation regulator 1 (Erdr1) has been identified as an anti-inflammatory factor in several disease models, including collagen-induced arthritis (CIA), but its exact mechanisms are still not fully understood. Here, the involvement of regulatory T (Treg) cells in Erdr1-improved CIA was investigated. In the CIA model, Erdr1 was confirmed to reduce collagen-specific IgM in plasma and plasma cells in draining lymph nodes. Importantly, the downregulated Treg cell ratio in draining lymph nodes from CIA mice was recovered by Erdr1 treatment. In addition, administration of Erdr1 improved the CIA score and joint tissue damage, while it revealed no effect in Treg cell-depleted CIA mice, indicating that Treg cells mediate the therapeutic effects of Erdr1 in the CIA model. Results from in vitro experiments also demonstrated that Erdr1 significantly induced Treg cell differentiation and the expression of Treg activation markers, including CD25, CD69, and CTLA4 in CD4+ Foxp3+ cells. Furthermore, Erdr1-activated Treg cells dramatically suppressed the proliferation of responder T cells, suggesting that they are functionally active. Taken together, these results show that Erdr1 induces activation of Treg cells and ameliorates rheumatoid arthritis via Treg cells.

Original languageEnglish
Article number9555
Pages (from-to)1-10
Number of pages10
JournalInternational journal of molecular sciences
Volume21
Issue number24
DOIs
Publication statusPublished - 2020 Dec 2

Keywords

  • Erythroid differentiation regulator 1
  • Regulatory T cells
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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