Erythroid differentiation regulator 1 strengthens TCR signaling in thymocytes by modulating calcium flux

Myun Soo Kim, Sora Lee, Su Jin Jung, Sunyoung Park, Kyung Eun Kim, Tae Sung Kim, Hyun Jeong Park, Daeho Cho

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Erythroid differentiation regulator 1 (Erdr1) has been identified as a stromal survival factor released under stressful conditions. Previously, Erdr1 was reported to be expressed highly in thymus, but roles of Erdr1 in thymus were not known. Here, the effects of Erdr1 on T cell development were investigated. The expression of Erdr1 was higher in thymus than bone marrow and Erdr1 was detected in both the cortex and medulla of thymus. Erdr1 treatment significantly induced the expression of activation marker, CD69, from thymocytes in the presence of TCR stimuli in vitro and the induction was dependent on increased Ca 2+ influx. In addition, in vivo administration of Erdr1 resulted in significant increase of total and positive selected thymocyte numbers, particularly in the number of CD3TCR hi CD69 + DP thymocytes. Taken together, our results show that Erdr1 enhances the strength of TCR signaling and cellularity of thymocytes by amplifying Ca 2+ influx in thymocytes receiving TCR signals.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalCellular Immunology
Volume336
DOIs
Publication statusPublished - 2019 Feb

Keywords

  • Calcium flux
  • Erdr1
  • TCR
  • Thymocyte

ASJC Scopus subject areas

  • Immunology

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