Erythropoietin attenuates hyperoxia-induced lung injury by down-modulating inflammation in neonatal rats

Hoon Lee Jang, Kyung Sung Dong, Hyun Koo Soo, Bong Kyung Shin, Young Sook Hong, Chang Sung Son, Won Lee Joo, Sil Chang Yun, Soon Park Won

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

This study was done to determine whether recombinant human erythropoietin (rhEPO) treatment could attenuate hyperoxia-induced lung injury, and if so, whether this protective effect is mediated by the down-modulation of inflammation in neonatal rats. Newborn Sprague Dawley rat pups were subjected to 14 days of hyperoxia (>95% oxygen) within 10 hr after birth. Treatment with rhEPO significantly attenuated the mortality and reduced body weight gain caused by hyperoxia. With rhEPO treatment, given 3 unit/gm intraperitoneally at 4th, 5th, and 6th postnatal day, hyperoxia-induced alterations in lung pathology such as decreased radial alveolar count, increased mean linear intercept, and fibrosis were significantly improved, and the inflammatory changes such as myeloperoxidase activity and tumor necrosis factor-alpha expression were also significantly attenuated. In summary, rhEPO treatment significantly attenuated hyperoxia-induced lung injury by down-modulating the inflammatory responses in neonatal rats.

Original languageEnglish
Pages (from-to)1042-1047
Number of pages6
JournalJournal of Korean Medical Science
Volume22
Issue number6
DOIs
Publication statusPublished - 2007 Dec 1

    Fingerprint

Keywords

  • Animals, newborn
  • Bronchopulmonary dysplasia
  • Erythropoietin
  • Inflammation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jang, H. L., Dong, K. S., Soo, H. K., Shin, B. K., Hong, Y. S., Son, C. S., Joo, W. L., Yun, S. C., & Won, S. P. (2007). Erythropoietin attenuates hyperoxia-induced lung injury by down-modulating inflammation in neonatal rats. Journal of Korean Medical Science, 22(6), 1042-1047. https://doi.org/10.3346/jkms.2008.22.6.1042