Escitalopram efficacy in depression: A cross-ethnicity examination of the serotonin transporter promoter polymorphism

Chad A. Bousman, Jerome Sarris, Eun Soo Won, Hun Soo Chang, Ajeet Singh, Hwa Young Lee, Byung-Joo Ham, Chay Hoon Tan, Min-Soo Lee, Chee H. Ng

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.

Original languageEnglish
Pages (from-to)645-648
Number of pages4
JournalJournal of Clinical Psychopharmacology
Volume34
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

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Serotonin Plasma Membrane Transport Proteins
Citalopram
Antidepressive Agents
Depression
Major Depressive Disorder
Genotype
Genes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Escitalopram efficacy in depression : A cross-ethnicity examination of the serotonin transporter promoter polymorphism. / Bousman, Chad A.; Sarris, Jerome; Won, Eun Soo; Chang, Hun Soo; Singh, Ajeet; Lee, Hwa Young; Ham, Byung-Joo; Tan, Chay Hoon; Lee, Min-Soo; Ng, Chee H.

In: Journal of Clinical Psychopharmacology, Vol. 34, No. 5, 01.01.2014, p. 645-648.

Research output: Contribution to journalArticle

Bousman, Chad A. ; Sarris, Jerome ; Won, Eun Soo ; Chang, Hun Soo ; Singh, Ajeet ; Lee, Hwa Young ; Ham, Byung-Joo ; Tan, Chay Hoon ; Lee, Min-Soo ; Ng, Chee H. / Escitalopram efficacy in depression : A cross-ethnicity examination of the serotonin transporter promoter polymorphism. In: Journal of Clinical Psychopharmacology. 2014 ; Vol. 34, No. 5. pp. 645-648.
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