Escitalopram efficacy in depression: A cross-ethnicity examination of the serotonin transporter promoter polymorphism

Chad A. Bousman, Jerome Sarris, Eun Soo Won, Hun Soo Chang, Ajeet Singh, Hwa Young Lee, Byung Joo Ham, Chay Hoon Tan, Min Soo Lee, Chee H. Ng

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.

Original languageEnglish
Pages (from-to)645-648
Number of pages4
JournalJournal of Clinical Psychopharmacology
Volume34
Issue number5
DOIs
Publication statusPublished - 2014 Oct
Externally publishedYes

Keywords

  • antidepressant
  • efficacy
  • genotype
  • pharmacogenetic

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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