Escitalopram efficacy in depression: A cross-ethnicity examination of the serotonin transporter promoter polymorphism

Chad A. Bousman, Jerome Sarris, Eun Soo Won, Hun Soo Chang, Ajeet Singh, Hwa Young Lee, Byung-Joo Ham, Chay Hoon Tan, Min-Soo Lee, Chee H. Ng

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.

Original languageEnglish
Pages (from-to)645-648
Number of pages4
JournalJournal of Clinical Psychopharmacology
Volume34
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Bousman, C. A., Sarris, J., Won, E. S., Chang, H. S., Singh, A., Lee, H. Y., Ham, B-J., Tan, C. H., Lee, M-S., & Ng, C. H. (2014). Escitalopram efficacy in depression: A cross-ethnicity examination of the serotonin transporter promoter polymorphism. Journal of Clinical Psychopharmacology, 34(5), 645-648. https://doi.org/10.1097/JCP.0000000000000165