Estimate of the risk of radiation-induced cancers after linear-accelerator-based breast-cancer radiotherapy

Eui Kwan Koh, Jungju Seo, Tae Seong Baek, Eun Ji Chung, Myonggeun Yoon, Hyun ho Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of this study is to assess and compare the excess absolute risks (EARs) of radiation-induced cancers following conformal (3D-CRT), fixed-field intensity-modulated (IMRT) and volumetric modulated arc (RapidArc) radiation therapy in patients with breast cancer. 3D-CRT, IMRT and RapidArc were planned for 10 breast cancer patients. The organ-specific EAR for cancer induction was estimated using the organ equivalent dose (OED) based on computed dose volume histograms (DVHs) and the secondary doses measured at various points from the field edge. The average secondary dose per Gy treatment dose from 3D-CRT, measured 10 to 50 cm from the field edge, ranged from 8.27 to 1.04 mGy. The secondary doses per Gy from IMRT and RapidArc, however, ranged between 5.86 and 0.54 mGy, indicating that IMRT and RapidArc are associated with smaller doses of secondary radiation than 3D-CRT. The organ specific EARs for out-of-field organs, such as the thyroid, liver and colon, were higher with 3D-CRT than with IMRT or RapidArc. In contrast, EARs for in-field organs were much lower with 3D-CRT than with IMRT or RapidArc. The overall estimate of EAR indicated that the radiation-induced cancer risk was 1.8-2.0 times lower with 3D-CRT than with IMRT or RapidArc. Comparisons of EARs during breast irradiation suggested that the predicted risk of secondary cancers was lower with 3D-CRT than with IMRT or RapidArc.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalJournal of the Korean Physical Society
Volume63
Issue number1
DOIs
Publication statusPublished - 2013 Jul

Keywords

  • Breast radiotherapy
  • EAR
  • OED
  • Radiation-induced cancer

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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