Estimation of the secondary cancer risk induced by diagnostic imaging radiation during proton therapy

Hojin Jeong, Jeong Eun Rah, Ui Jung Hwang, Seung Hoon Yoo, Byung Jun Min, Sang Yeob Lee, Myonggeun Yoon, Dong Ho Shin, Sung Yong Park, Se Byeong Lee, Joo Young Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We have estimated the secondary cancer risk (SCR) introduced by image-guided procedures during proton therapy. The physical dose from imaging radiation and the corresponding organ equivalent dose were calculated for the case of a lumbar spine patient. The maximum physical dose delivered to the patient during the imaging procedure was estimated to be ∼ 0.35% of the prescribed dose of 46Gy. However, this small imaging dose substantially raised the radiation-induced SCR by ∼ 8%. In addition, the clinical benefit (improved accuracy during the procedure) and costs (extra SCR) associated with image-guided procedures were quantitatively modelled by systematically investigating the changes in SCR as a function of the prescribed dose, treatment target volume and imaging field size. The results showed that the SCR varied sensitively with the volume receiving the imaging and the therapeutic radiation, whereas the SCR depended to a lesser extent on the magnitude of the applied therapeutic radiation. These results showed that the additional SCR introduced by imaging radiation could be efficiently reduced by minimizing the imaging field size during image-guided procedures.

Original languageEnglish
Pages (from-to)477-487
Number of pages11
JournalJournal of Radiological Protection
Volume31
Issue number4
DOIs
Publication statusPublished - 2011 Dec 1
Externally publishedYes

Fingerprint

Proton Therapy
Diagnostic Imaging
Radiation
Neoplasms
Radiation-Induced Neoplasms
radiation
cancer risk
therapy
Spine
Therapeutics
dose
Costs and Cost Analysis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Waste Management and Disposal
  • Medicine(all)

Cite this

Estimation of the secondary cancer risk induced by diagnostic imaging radiation during proton therapy. / Jeong, Hojin; Rah, Jeong Eun; Hwang, Ui Jung; Yoo, Seung Hoon; Min, Byung Jun; Lee, Sang Yeob; Yoon, Myonggeun; Shin, Dong Ho; Park, Sung Yong; Lee, Se Byeong; Kim, Joo Young.

In: Journal of Radiological Protection, Vol. 31, No. 4, 01.12.2011, p. 477-487.

Research output: Contribution to journalArticle

Jeong, H, Rah, JE, Hwang, UJ, Yoo, SH, Min, BJ, Lee, SY, Yoon, M, Shin, DH, Park, SY, Lee, SB & Kim, JY 2011, 'Estimation of the secondary cancer risk induced by diagnostic imaging radiation during proton therapy', Journal of Radiological Protection, vol. 31, no. 4, pp. 477-487. https://doi.org/10.1088/0952-4746/31/4/007
Jeong, Hojin ; Rah, Jeong Eun ; Hwang, Ui Jung ; Yoo, Seung Hoon ; Min, Byung Jun ; Lee, Sang Yeob ; Yoon, Myonggeun ; Shin, Dong Ho ; Park, Sung Yong ; Lee, Se Byeong ; Kim, Joo Young. / Estimation of the secondary cancer risk induced by diagnostic imaging radiation during proton therapy. In: Journal of Radiological Protection. 2011 ; Vol. 31, No. 4. pp. 477-487.
@article{52d9ad98119645b9a90b60a0fbc390b1,
title = "Estimation of the secondary cancer risk induced by diagnostic imaging radiation during proton therapy",
abstract = "We have estimated the secondary cancer risk (SCR) introduced by image-guided procedures during proton therapy. The physical dose from imaging radiation and the corresponding organ equivalent dose were calculated for the case of a lumbar spine patient. The maximum physical dose delivered to the patient during the imaging procedure was estimated to be ∼ 0.35{\%} of the prescribed dose of 46Gy. However, this small imaging dose substantially raised the radiation-induced SCR by ∼ 8{\%}. In addition, the clinical benefit (improved accuracy during the procedure) and costs (extra SCR) associated with image-guided procedures were quantitatively modelled by systematically investigating the changes in SCR as a function of the prescribed dose, treatment target volume and imaging field size. The results showed that the SCR varied sensitively with the volume receiving the imaging and the therapeutic radiation, whereas the SCR depended to a lesser extent on the magnitude of the applied therapeutic radiation. These results showed that the additional SCR introduced by imaging radiation could be efficiently reduced by minimizing the imaging field size during image-guided procedures.",
author = "Hojin Jeong and Rah, {Jeong Eun} and Hwang, {Ui Jung} and Yoo, {Seung Hoon} and Min, {Byung Jun} and Lee, {Sang Yeob} and Myonggeun Yoon and Shin, {Dong Ho} and Park, {Sung Yong} and Lee, {Se Byeong} and Kim, {Joo Young}",
year = "2011",
month = "12",
day = "1",
doi = "10.1088/0952-4746/31/4/007",
language = "English",
volume = "31",
pages = "477--487",
journal = "Journal of Radiological Protection",
issn = "0952-4746",
publisher = "IOP Publishing Ltd.",
number = "4",

}

TY - JOUR

T1 - Estimation of the secondary cancer risk induced by diagnostic imaging radiation during proton therapy

AU - Jeong, Hojin

AU - Rah, Jeong Eun

AU - Hwang, Ui Jung

AU - Yoo, Seung Hoon

AU - Min, Byung Jun

AU - Lee, Sang Yeob

AU - Yoon, Myonggeun

AU - Shin, Dong Ho

AU - Park, Sung Yong

AU - Lee, Se Byeong

AU - Kim, Joo Young

PY - 2011/12/1

Y1 - 2011/12/1

N2 - We have estimated the secondary cancer risk (SCR) introduced by image-guided procedures during proton therapy. The physical dose from imaging radiation and the corresponding organ equivalent dose were calculated for the case of a lumbar spine patient. The maximum physical dose delivered to the patient during the imaging procedure was estimated to be ∼ 0.35% of the prescribed dose of 46Gy. However, this small imaging dose substantially raised the radiation-induced SCR by ∼ 8%. In addition, the clinical benefit (improved accuracy during the procedure) and costs (extra SCR) associated with image-guided procedures were quantitatively modelled by systematically investigating the changes in SCR as a function of the prescribed dose, treatment target volume and imaging field size. The results showed that the SCR varied sensitively with the volume receiving the imaging and the therapeutic radiation, whereas the SCR depended to a lesser extent on the magnitude of the applied therapeutic radiation. These results showed that the additional SCR introduced by imaging radiation could be efficiently reduced by minimizing the imaging field size during image-guided procedures.

AB - We have estimated the secondary cancer risk (SCR) introduced by image-guided procedures during proton therapy. The physical dose from imaging radiation and the corresponding organ equivalent dose were calculated for the case of a lumbar spine patient. The maximum physical dose delivered to the patient during the imaging procedure was estimated to be ∼ 0.35% of the prescribed dose of 46Gy. However, this small imaging dose substantially raised the radiation-induced SCR by ∼ 8%. In addition, the clinical benefit (improved accuracy during the procedure) and costs (extra SCR) associated with image-guided procedures were quantitatively modelled by systematically investigating the changes in SCR as a function of the prescribed dose, treatment target volume and imaging field size. The results showed that the SCR varied sensitively with the volume receiving the imaging and the therapeutic radiation, whereas the SCR depended to a lesser extent on the magnitude of the applied therapeutic radiation. These results showed that the additional SCR introduced by imaging radiation could be efficiently reduced by minimizing the imaging field size during image-guided procedures.

UR - http://www.scopus.com/inward/record.url?scp=81555208815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81555208815&partnerID=8YFLogxK

U2 - 10.1088/0952-4746/31/4/007

DO - 10.1088/0952-4746/31/4/007

M3 - Article

VL - 31

SP - 477

EP - 487

JO - Journal of Radiological Protection

JF - Journal of Radiological Protection

SN - 0952-4746

IS - 4

ER -