Estrogen regulation of phosphoserine phosphatase during regression and recrudescence of female reproductive organs

Ji Young Lee, Whasun Lim, Gahee Jo, Fuller W. Bazer, Gwonhwa Song

Research output: Contribution to journalArticle

Abstract

Phosphoserine phosphatase (PSPH) is a well-known mediator of l-serine biosynthesis in a variety of tissues and its dysregulation causes various diseases, specifically most cancers. However, little is known about the expression and hormonal regulation of PSPH gene in the female reproductive tract. Therefore, in the current study, we focused on relationships between PSPH expression and estrogen during growth, development, differentiation, remodeling and recrudescence of the chicken oviduct and in the progression of epithelial-derived ovarian carcinogenesis in laying hens. The results revealed that PSPH mRNA and protein levels increased in the glandular (GE) and luminal epithelial (LE) cells in the developing oviduct of chicks treated with exogenous estrogen. Additionally, PSPH mRNA and protein expression was up-regulated in GE and LE of the oviduct in response to endogenous estrogen during the recrudescence phase after induced molting. Furthermore, PSPH mRNA and protein were predominantly detected in GE of cancerous, but not normal ovaries. In conclusion, PSPH is a novel estrogen-responsive gene involved in development of the oviduct of chicks and recrudescence of the oviduct of laying hens after molting. PSPH is also a potential target molecule that may help elucidate mechanism responsible for the progression of epithelial cell-derived ovarian carcinogenesis and be of use in therapeutic applications as a biomarker for early diagnosis of epithelial cell-derived ovarian cancer in laying hen as well as women.

Original languageEnglish
Pages (from-to)40-46
Number of pages7
JournalGeneral and Comparative Endocrinology
Volume214
DOIs
Publication statusPublished - 2015 Apr 1

Fingerprint

Estrogens
Oviducts
Recurrence
Molting
Epithelial Cells
Messenger RNA
Carcinogenesis
Proteins
phosphoserine phosphatase
Therapeutic Uses
Growth and Development
Ovarian Neoplasms
Serine
Genes
Early Diagnosis
Ovary
Chickens
Biomarkers
Neoplasms

Keywords

  • Estrogen
  • Ovarian cancer
  • Ovary
  • Oviduct
  • PSPH

ASJC Scopus subject areas

  • Endocrinology

Cite this

Estrogen regulation of phosphoserine phosphatase during regression and recrudescence of female reproductive organs. / Lee, Ji Young; Lim, Whasun; Jo, Gahee; Bazer, Fuller W.; Song, Gwonhwa.

In: General and Comparative Endocrinology, Vol. 214, 01.04.2015, p. 40-46.

Research output: Contribution to journalArticle

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