Estrogenic activity of a Rhus verniciflua extract and its major components

Seunghan Sun, Yun Ho Choi, Chun Soo Na, Dongho Lee, Hye Hyun Yoo, Cheol Yi Hong, Byung-Yoon Ahn, Mi Sook Dong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Rhus verniciflua Stokes has been used as a traditional herbal medicine, a food additive, and a material for lacquer in Korea. In this study, hot water extracts of R. verniciflua Stokes xylem (RVE) and purified compounds were examined for estrogenic activity. RVE showed estrogenic activity mediated by estrogen receptors (ER) with a higher binding affinity and activity to ERβ than to ERα in ERα- or ERβ-transfected cells. It also exhibited estrogenic activity in a uterotrophic assay using rats. All of RVE compounds had high affinity to ERβ compared with ERα in reporter gene assay and ER binding assay. Among seven RVE compounds, butin, butein, sulfuretin, and garbanzol had a strong estrogenic activity in ERE-mediated reporter gene assay. Butein and sulfuretin had stronger ERβ binding affinity compared with others. Collectively, these results demonstrate an estrogenic activity of RVE and suggest its potential value for postmenopausal women.

Original languageEnglish
Pages (from-to)250-260
Number of pages11
JournalJournal of Functional Foods
Volume11
Issue numberC
DOIs
Publication statusPublished - 2014

Fingerprint

Toxicodendron vernicifluum
Rhus
estrogenic properties
Estrogen Receptors
extracts
assays
Reporter Genes
reporter genes
Lacquer
estrogen receptors
Xylem
Food Additives
Herbal Medicine
herbal medicines
food additives
Traditional Medicine
Korea
Korean Peninsula
xylem

Keywords

  • Estrogen receptor α and β
  • Estrogenic activity
  • Reporter gene assay
  • Rhus verniciflua stokes
  • Uterotrophic assay

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Sun, S., Choi, Y. H., Na, C. S., Lee, D., Yoo, H. H., Hong, C. Y., ... Dong, M. S. (2014). Estrogenic activity of a Rhus verniciflua extract and its major components. Journal of Functional Foods, 11(C), 250-260. https://doi.org/10.1016/j.jff.2014.09.014

Estrogenic activity of a Rhus verniciflua extract and its major components. / Sun, Seunghan; Choi, Yun Ho; Na, Chun Soo; Lee, Dongho; Yoo, Hye Hyun; Hong, Cheol Yi; Ahn, Byung-Yoon; Dong, Mi Sook.

In: Journal of Functional Foods, Vol. 11, No. C, 2014, p. 250-260.

Research output: Contribution to journalArticle

Sun, Seunghan ; Choi, Yun Ho ; Na, Chun Soo ; Lee, Dongho ; Yoo, Hye Hyun ; Hong, Cheol Yi ; Ahn, Byung-Yoon ; Dong, Mi Sook. / Estrogenic activity of a Rhus verniciflua extract and its major components. In: Journal of Functional Foods. 2014 ; Vol. 11, No. C. pp. 250-260.
@article{a78f4df1fffe470c8c234622d7a9299e,
title = "Estrogenic activity of a Rhus verniciflua extract and its major components",
abstract = "Rhus verniciflua Stokes has been used as a traditional herbal medicine, a food additive, and a material for lacquer in Korea. In this study, hot water extracts of R. verniciflua Stokes xylem (RVE) and purified compounds were examined for estrogenic activity. RVE showed estrogenic activity mediated by estrogen receptors (ER) with a higher binding affinity and activity to ERβ than to ERα in ERα- or ERβ-transfected cells. It also exhibited estrogenic activity in a uterotrophic assay using rats. All of RVE compounds had high affinity to ERβ compared with ERα in reporter gene assay and ER binding assay. Among seven RVE compounds, butin, butein, sulfuretin, and garbanzol had a strong estrogenic activity in ERE-mediated reporter gene assay. Butein and sulfuretin had stronger ERβ binding affinity compared with others. Collectively, these results demonstrate an estrogenic activity of RVE and suggest its potential value for postmenopausal women.",
keywords = "Estrogen receptor α and β, Estrogenic activity, Reporter gene assay, Rhus verniciflua stokes, Uterotrophic assay",
author = "Seunghan Sun and Choi, {Yun Ho} and Na, {Chun Soo} and Dongho Lee and Yoo, {Hye Hyun} and Hong, {Cheol Yi} and Byung-Yoon Ahn and Dong, {Mi Sook}",
year = "2014",
doi = "10.1016/j.jff.2014.09.014",
language = "English",
volume = "11",
pages = "250--260",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier Limited",
number = "C",

}

TY - JOUR

T1 - Estrogenic activity of a Rhus verniciflua extract and its major components

AU - Sun, Seunghan

AU - Choi, Yun Ho

AU - Na, Chun Soo

AU - Lee, Dongho

AU - Yoo, Hye Hyun

AU - Hong, Cheol Yi

AU - Ahn, Byung-Yoon

AU - Dong, Mi Sook

PY - 2014

Y1 - 2014

N2 - Rhus verniciflua Stokes has been used as a traditional herbal medicine, a food additive, and a material for lacquer in Korea. In this study, hot water extracts of R. verniciflua Stokes xylem (RVE) and purified compounds were examined for estrogenic activity. RVE showed estrogenic activity mediated by estrogen receptors (ER) with a higher binding affinity and activity to ERβ than to ERα in ERα- or ERβ-transfected cells. It also exhibited estrogenic activity in a uterotrophic assay using rats. All of RVE compounds had high affinity to ERβ compared with ERα in reporter gene assay and ER binding assay. Among seven RVE compounds, butin, butein, sulfuretin, and garbanzol had a strong estrogenic activity in ERE-mediated reporter gene assay. Butein and sulfuretin had stronger ERβ binding affinity compared with others. Collectively, these results demonstrate an estrogenic activity of RVE and suggest its potential value for postmenopausal women.

AB - Rhus verniciflua Stokes has been used as a traditional herbal medicine, a food additive, and a material for lacquer in Korea. In this study, hot water extracts of R. verniciflua Stokes xylem (RVE) and purified compounds were examined for estrogenic activity. RVE showed estrogenic activity mediated by estrogen receptors (ER) with a higher binding affinity and activity to ERβ than to ERα in ERα- or ERβ-transfected cells. It also exhibited estrogenic activity in a uterotrophic assay using rats. All of RVE compounds had high affinity to ERβ compared with ERα in reporter gene assay and ER binding assay. Among seven RVE compounds, butin, butein, sulfuretin, and garbanzol had a strong estrogenic activity in ERE-mediated reporter gene assay. Butein and sulfuretin had stronger ERβ binding affinity compared with others. Collectively, these results demonstrate an estrogenic activity of RVE and suggest its potential value for postmenopausal women.

KW - Estrogen receptor α and β

KW - Estrogenic activity

KW - Reporter gene assay

KW - Rhus verniciflua stokes

KW - Uterotrophic assay

UR - http://www.scopus.com/inward/record.url?scp=84926347052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926347052&partnerID=8YFLogxK

U2 - 10.1016/j.jff.2014.09.014

DO - 10.1016/j.jff.2014.09.014

M3 - Article

VL - 11

SP - 250

EP - 260

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

IS - C

ER -