Abstract
We report that a Lewis acidic silane, Me 2 SiHCl, can mediate the direct cross-coupling of a wide range of carbonyl compounds with alcohols to form dialkyl ethers. The reaction is operationally simple, tolerates a range of polar functional groups, can be utilized to make sterically hindered ethers, and is extendable to sulfur and nitrogen nucleophiles.
Original language | English |
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Pages (from-to) | 2425-2428 |
Number of pages | 4 |
Journal | Synlett |
Volume | 28 |
Issue number | 18 |
DOIs | |
Publication status | Published - 2017 Nov 13 |
Externally published | Yes |
Keywords
- alcohols
- ethers
- ketones
- Lewis acid
- reductive coupling
- silanes
ASJC Scopus subject areas
- Organic Chemistry