Ether Synthesis through Reductive Cross-Coupling of Ketones with Alcohols Using Me 2 SiHCl as both Reductant and Lewis Acid

Yong Ho Lee, Bill Morandi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We report that a Lewis acidic silane, Me 2 SiHCl, can mediate the direct cross-coupling of a wide range of carbonyl compounds with alcohols to form dialkyl ethers. The reaction is operationally simple, tolerates a range of polar functional groups, can be utilized to make sterically hindered ethers, and is extendable to sulfur and nitrogen nucleophiles.

Original languageEnglish
Pages (from-to)2425-2428
Number of pages4
JournalSynlett
Volume28
Issue number18
DOIs
Publication statusPublished - 2017 Nov 13
Externally publishedYes

Keywords

  • alcohols
  • ethers
  • ketones
  • Lewis acid
  • reductive coupling
  • silanes

ASJC Scopus subject areas

  • Organic Chemistry

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