Ethnic differences in the association of the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric carcinoma: A systematic review and meta-analysis

Jeongmin Yoon, Myung Han Hyun, Jong Pill Yang, Min Jeong Park, Sungsoo Park

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We performed a systematic review and meta-analysis of the association between the glutathione S-transferase T1 (GSTT1) deletion polymorphism and gastric cancer risk in populations from different ethnic backgrounds, based on a comprehensive literature search of the MEDLINE, EMBASE, and COCHRANE libraries. Thirty-six individual case-control studies comprising 7,689 gastric cancer cases and 12,445 controls were included in our meta-analysis. Overall, the GSTT1 null genotype appeared to increase gastric cancer risk (OR 1.17, 95 % CI 1.06-1.31, p = 0.003). While Caucasian populations showed an association between the GSTT1 deletion polymorphism and gastric cancer risk (OR 1.27, 95 % CI 1.05-1.52, p = 0.01), Asian populations did not show such an association (p = 0.11). When stratified by quality assessment scores, a significant association between the GSTT1 deletion polymorphism and gastric cancer risk was observed only in the Caucasian high quality subgroup (OR 1.27 95 % CI 1.01-1.60, p = 0.05). Null genotypes for both GSTT1 and GSTM1 deletion polymorphisms also increased gastric cancer risk (OR 1.37, 95 % CI 1.04-1.80, p = 0.03). Our study suggests that the GSTT1 null genotype is associated with a significant increase in gastric cancer risk in Caucasians, but not in Asians. Further well-designed studies are required to confirm the association between GSTT1 polymorphisms and gastric cancer risk in relation to various clinicopathological factors in different ethnic groups, especially Caucasians.

Original languageEnglish
Pages (from-to)3867-3879
Number of pages13
JournalMolecular Biology Reports
Volume41
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Stomach Neoplasms
Meta-Analysis
Stomach
Genotype
Carcinoma
Population
glutathione S-transferase T1
Ethnic Groups
MEDLINE
Libraries
Case-Control Studies

Keywords

  • Genetic
  • Glutathione S-transferase T1
  • GSTT1
  • Polymorphism
  • Risk
  • Single nucleotide
  • Stomach neoplasms

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Ethnic differences in the association of the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric carcinoma : A systematic review and meta-analysis. / Yoon, Jeongmin; Hyun, Myung Han; Yang, Jong Pill; Park, Min Jeong; Park, Sungsoo.

In: Molecular Biology Reports, Vol. 41, No. 6, 01.01.2014, p. 3867-3879.

Research output: Contribution to journalArticle

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