Etiology and clinical outcomes of acute respiratory virus infection in hospitalized adults

Yu Bin Seo, Joon-Young Song, Min Ju Choi, In Seon Kim, Tea Un Yang, Kyung Wook Hong, Hee-Jin Cheong, Woo Joo Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Etiologies and clinical profiles of acute respiratory viral infections need to be clarified to improve preventive and therapeutic strategies. Materials and Methods: A retrospective observational study at a single, university-affiliated center was performed to evaluate the respiratory viral infection etiologies in children compared to that in adults and to document the clinical features of common viral infections for adults from July 2009 to April 2012. Results: The common viruses detected from children (2,800 total patients) were human rhinovirus (hRV) (31.8%), adenovirus (AdV) (19.2%), respiratory syncytial virus (RSV) A (17.4%), RSV B (11.7%), and human metapneumovirus (hMPV) (9.8%). In comparison, influenza virus A (IFA) had the highest isolation rate (28.5%), followed by hRV (15.5%), influenza virus B (IFB) (15.0%), and hMPV (14.0%), in adults (763 total patients). Multiple viruses were detected in single specimens from 22.4% of children and 2.0% of adults. IFA/IFB, RSV A/B, and hMPV exhibited strong seasonal detection and similar circulating patterns in children and adults. Adult patients showed different clinical manifestations according to causative viruses; nasal congestion and rhinorrhea were more common in hRV and human coronavirus (hCoV) infection. Patients with RSV B, hRV, or AdV tended to be younger, and those infected with RSV A and hMPV were likely to be older. Those with RSV A infection tended to stay longer in hospital, enter the intensive care unit more frequently, and have a fatal outcome more often. The bacterial co-detection rate was 26.5%, and those cases were more likely to have lower respiratory tract involvement (P = 0.001), longer hospital stay (P = 0.001), and higher mortality (P = 0.001).Conclusions: The etiologic virus of an acute respiratory infection can be cautiously inferred based on a patient's age and clinical features and concurrent epidemic data. Large-scale prospective surveillance studies are required to provide more accurate information about respiratory viral infection etiology, which could favorably influence clinical outcomes.

Original languageEnglish
Pages (from-to)67-76
Number of pages10
JournalInfection and Chemotherapy
Volume46
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

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Metapneumovirus
Virus Diseases
Rhinovirus
Respiratory Tract Infections
Respiratory Syncytial Viruses
Influenza A virus
Viruses
Influenza B virus
Adenoviridae
Coronavirus Infections
Human respiratory syncytial virus
Respiratory Syncytial Virus Infections
Fatal Outcome
Nose
Respiratory System
Observational Studies
Intensive Care Units
Length of Stay
Retrospective Studies
Prospective Studies

Keywords

  • Adult
  • Children
  • Etiology
  • Respiratory virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Etiology and clinical outcomes of acute respiratory virus infection in hospitalized adults. / Seo, Yu Bin; Song, Joon-Young; Choi, Min Ju; Kim, In Seon; Yang, Tea Un; Hong, Kyung Wook; Cheong, Hee-Jin; Kim, Woo Joo.

In: Infection and Chemotherapy, Vol. 46, No. 2, 01.01.2014, p. 67-76.

Research output: Contribution to journalArticle

Seo, Yu Bin ; Song, Joon-Young ; Choi, Min Ju ; Kim, In Seon ; Yang, Tea Un ; Hong, Kyung Wook ; Cheong, Hee-Jin ; Kim, Woo Joo. / Etiology and clinical outcomes of acute respiratory virus infection in hospitalized adults. In: Infection and Chemotherapy. 2014 ; Vol. 46, No. 2. pp. 67-76.
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