Etiology of invasive bacterial infections in immunocompetent children in Korea (1996-2005): A retrospective multicenter study

Joon Ho Lee, Hye Kyung Cho, Kyung Hyo Kim, Chang Hwi Kim, Dong Soo Kim, Kwang Nam Kim, Sung Ho Cha, Sung Hee Oh, Jae Kyun Hur, Jin Han Kang, Jong Hyun Kim, Yun Kyung Kim, Young Jin Hong, Eun Hee Chung, Soo Eun Park, Young Youn Choi, Jung Soo Kim, Hwang Min Kim, Eun Hwa Choi, Hoan Jong Lee

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Abstract

The purpose of this study was to identify the major etiological agents responsible for invasive bacterial infections in immunocompetent Korean children. We retrospectively surveyed invasive bacterial infections in immunocompetent children caused by eight major pediatric bacteria, namely Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pyogenes, Listeria monocytogenes, and Salmonella species that were diagnosed at 18 university hospitals from 1996 to 2005. A total of 768 cases were identified. S. agalactiae (48.1%) and S. aureus (37.2%) were the most common pathogens in infants younger than 3 months. S. agalactiae was a common cause of meningitis (73.0%), bacteremia without localization (34.0%), and arthritis (50%) in this age group. S. pneumoniae (45.3%) and H. influenzae (20.4%) were common in children aged 3 months to 5 yr. S. pneumoniae was a common cause of meningitis (41.6%), bacteremia without localization (40.0%), and bacteremic pneumonia (74.1%) in this age group. S. aureus (50.6%), Salmonella species (16.9%), and S. pneumoniae (16.3%) were common in older children. A significant decline in H. influenzae infections over the last 10 yr was noted. S. agalactiae, S. pneumoniae, and S. aureus are important pathogens responsible for invasive bacterial infections in Korean children.

Original languageEnglish
Pages (from-to)174-183
Number of pages10
JournalJournal of Korean Medical Science
Volume26
Issue number2
DOIs
Publication statusPublished - 2011 Feb 1

Fingerprint

Korea
Streptococcus pneumoniae
Bacterial Infections
Streptococcus agalactiae
Multicenter Studies
Retrospective Studies
Staphylococcus aureus
Haemophilus influenzae
Bacteremia
Meningitis
Salmonella
Age Groups
Haemophilus Infections
Neisseria meningitidis
Streptococcus pyogenes
Listeria monocytogenes
Arthritis
Pneumonia
Pediatrics
Bacteria

Keywords

  • Bacteremia
  • Bacterial infections
  • Epidemiology
  • Meningitis
  • Staphylococcus aureus
  • Streptococcus agalactiae
  • Streptococcus pneumonia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Etiology of invasive bacterial infections in immunocompetent children in Korea (1996-2005) : A retrospective multicenter study. / Lee, Joon Ho; Cho, Hye Kyung; Kim, Kyung Hyo; Kim, Chang Hwi; Kim, Dong Soo; Kim, Kwang Nam; Cha, Sung Ho; Oh, Sung Hee; Hur, Jae Kyun; Kang, Jin Han; Kim, Jong Hyun; Kim, Yun Kyung; Hong, Young Jin; Chung, Eun Hee; Park, Soo Eun; Choi, Young Youn; Kim, Jung Soo; Kim, Hwang Min; Choi, Eun Hwa; Lee, Hoan Jong.

In: Journal of Korean Medical Science, Vol. 26, No. 2, 01.02.2011, p. 174-183.

Research output: Contribution to journalArticle

Lee, JH, Cho, HK, Kim, KH, Kim, CH, Kim, DS, Kim, KN, Cha, SH, Oh, SH, Hur, JK, Kang, JH, Kim, JH, Kim, YK, Hong, YJ, Chung, EH, Park, SE, Choi, YY, Kim, JS, Kim, HM, Choi, EH & Lee, HJ 2011, 'Etiology of invasive bacterial infections in immunocompetent children in Korea (1996-2005): A retrospective multicenter study', Journal of Korean Medical Science, vol. 26, no. 2, pp. 174-183. https://doi.org/10.3346/jkms.2011.26.2.174
Lee, Joon Ho ; Cho, Hye Kyung ; Kim, Kyung Hyo ; Kim, Chang Hwi ; Kim, Dong Soo ; Kim, Kwang Nam ; Cha, Sung Ho ; Oh, Sung Hee ; Hur, Jae Kyun ; Kang, Jin Han ; Kim, Jong Hyun ; Kim, Yun Kyung ; Hong, Young Jin ; Chung, Eun Hee ; Park, Soo Eun ; Choi, Young Youn ; Kim, Jung Soo ; Kim, Hwang Min ; Choi, Eun Hwa ; Lee, Hoan Jong. / Etiology of invasive bacterial infections in immunocompetent children in Korea (1996-2005) : A retrospective multicenter study. In: Journal of Korean Medical Science. 2011 ; Vol. 26, No. 2. pp. 174-183.
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