Etiology of invasive bacterial infections in immunocompetent children in Korea (2006-2010): A retrospective multicenter study

Kyuyol Rhie, Eun Hwa Choi, Eun Young Cho, Jina Lee, Jin Han Kang, Dong Soo Kim, Yae Jean Kim, Youngmin Ahn, Byung Wook Eun, Sung Hee Oh, Sung Ho Cha, Young Jin Hong, Kwang Nam Kim, Nam Hee Kim, Yun Kyung Kim, Jong Hyun Kim, Taekjin Lee, Hwang Min Kim, Kun Song Lee, Chun Soo KimSu Eun Park, Young Mi Kim, Chi Eun Oh, Sang Hyuk Ma, Dae Sun Jo, Young Youn Choi, Hoan Jong Lee

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Abstract

Background: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. Methods: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005. Results: Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age. S. agalactiae was the most prevalent cause of meningitis and pneumonia and E. coli was the major cause of bacteremia without localizing signs in this group. In children 3 to 59 months of age, Streptococcus pneumoniae (54.2%), S. aureus (20.5%), and Salmonella spp. (14.4%) were the most common pathogens. S. pneumoniae was the leading cause of pneumonia (86.0%), meningitis (65.0%), and bacteremia without localizing signs (49.0%) in this group. In children ≥ 5 years of age, S. aureus (62.8%) was the predominant pathogen, followed by Salmonella species (12.4%) and S. pneumoniae (11.5%). Salmonella species (43.0%) was the most common cause of bacteremia without localizing signs in this group. The relative proportion of S. aureus increased significantly over the 15-year period (1996-2010) in children ≥ 3 months of age (P < 0.001), while that of Haemophilus influenzae decreased significantly in both < 3 months of age group (P = 0.036) and ≥ 3 months of age groups (P < 0.001). Conclusion: S. agalactiae, E. coli, S. pneumoniae, and S. aureus are common etiologic agents of invasive bacterial infections in Korean children.

Original languageEnglish
Article numbere45
JournalJournal of Korean Medical Science
Volume33
Issue number6
DOIs
Publication statusPublished - 2018 Jan 1

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Keywords

  • Bacterial infections
  • Epidemiology
  • Escherichia coli
  • Staphylococcus aureus
  • Streptococcus agalactiae
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rhie, K., Choi, E. H., Cho, E. Y., Lee, J., Kang, J. H., Kim, D. S., Kim, Y. J., Ahn, Y., Eun, B. W., Oh, S. H., Cha, S. H., Hong, Y. J., Kim, K. N., Kim, N. H., Kim, Y. K., Kim, J. H., Lee, T., Kim, H. M., Lee, K. S., ... Lee, H. J. (2018). Etiology of invasive bacterial infections in immunocompetent children in Korea (2006-2010): A retrospective multicenter study. Journal of Korean Medical Science, 33(6), [e45]. https://doi.org/10.3346/jkms.2018.33.e45