Etiology of invasive bacterial infections in immunocompetent children in Korea (2006-2010): A retrospective multicenter study

Kyuyol Rhie, Eun Hwa Choi, Eun Young Cho, Jina Lee, Jin Han Kang, Dong Soo Kim, Yae Jean Kim, Youngmin Ahn, Byung Wook Eun, Sung Hee Oh, Sung Ho Cha, Young Jin Hong, Kwang Nam Kim, Nam Hee Kim, Yun Kyung Kim, Jong Hyun Kim, Taekjin Lee, Hwang Min Kim, Kun Song Lee, Chun Soo KimSu Eun Park, Young Mi Kim, Chi Eun Oh, Sang Hyuk Ma, Dae Sun Jo, Young Youn Choi, Hoan Jong Lee

Research output: Contribution to journalArticle

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Abstract

Background: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. Methods: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005. Results: Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age. S. agalactiae was the most prevalent cause of meningitis and pneumonia and E. coli was the major cause of bacteremia without localizing signs in this group. In children 3 to 59 months of age, Streptococcus pneumoniae (54.2%), S. aureus (20.5%), and Salmonella spp. (14.4%) were the most common pathogens. S. pneumoniae was the leading cause of pneumonia (86.0%), meningitis (65.0%), and bacteremia without localizing signs (49.0%) in this group. In children ≥ 5 years of age, S. aureus (62.8%) was the predominant pathogen, followed by Salmonella species (12.4%) and S. pneumoniae (11.5%). Salmonella species (43.0%) was the most common cause of bacteremia without localizing signs in this group. The relative proportion of S. aureus increased significantly over the 15-year period (1996-2010) in children ≥ 3 months of age (P < 0.001), while that of Haemophilus influenzae decreased significantly in both < 3 months of age group (P = 0.036) and ≥ 3 months of age groups (P < 0.001). Conclusion: S. agalactiae, E. coli, S. pneumoniae, and S. aureus are common etiologic agents of invasive bacterial infections in Korean children.

Original languageEnglish
Article numbere45
JournalJournal of Korean Medical Science
Volume33
Issue number6
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Korea
Bacterial Infections
Multicenter Studies
Staphylococcus aureus
Streptococcus pneumoniae
Retrospective Studies
Streptococcus agalactiae
Bacteremia
Salmonella
Pneumonia
Escherichia coli Meningitis
Age Groups
Escherichia coli
Haemophilus influenzae
Meningitis

Keywords

  • Bacterial infections
  • Epidemiology
  • Escherichia coli
  • Staphylococcus aureus
  • Streptococcus agalactiae
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Etiology of invasive bacterial infections in immunocompetent children in Korea (2006-2010) : A retrospective multicenter study. / Rhie, Kyuyol; Choi, Eun Hwa; Cho, Eun Young; Lee, Jina; Kang, Jin Han; Kim, Dong Soo; Kim, Yae Jean; Ahn, Youngmin; Eun, Byung Wook; Oh, Sung Hee; Cha, Sung Ho; Hong, Young Jin; Kim, Kwang Nam; Kim, Nam Hee; Kim, Yun Kyung; Kim, Jong Hyun; Lee, Taekjin; Kim, Hwang Min; Lee, Kun Song; Kim, Chun Soo; Park, Su Eun; Kim, Young Mi; Oh, Chi Eun; Ma, Sang Hyuk; Jo, Dae Sun; Choi, Young Youn; Lee, Hoan Jong.

In: Journal of Korean Medical Science, Vol. 33, No. 6, e45, 01.01.2018.

Research output: Contribution to journalArticle

Rhie, K, Choi, EH, Cho, EY, Lee, J, Kang, JH, Kim, DS, Kim, YJ, Ahn, Y, Eun, BW, Oh, SH, Cha, SH, Hong, YJ, Kim, KN, Kim, NH, Kim, YK, Kim, JH, Lee, T, Kim, HM, Lee, KS, Kim, CS, Park, SE, Kim, YM, Oh, CE, Ma, SH, Jo, DS, Choi, YY & Lee, HJ 2018, 'Etiology of invasive bacterial infections in immunocompetent children in Korea (2006-2010): A retrospective multicenter study', Journal of Korean Medical Science, vol. 33, no. 6, e45. https://doi.org/10.3346/jkms.2018.33.e45
Rhie, Kyuyol ; Choi, Eun Hwa ; Cho, Eun Young ; Lee, Jina ; Kang, Jin Han ; Kim, Dong Soo ; Kim, Yae Jean ; Ahn, Youngmin ; Eun, Byung Wook ; Oh, Sung Hee ; Cha, Sung Ho ; Hong, Young Jin ; Kim, Kwang Nam ; Kim, Nam Hee ; Kim, Yun Kyung ; Kim, Jong Hyun ; Lee, Taekjin ; Kim, Hwang Min ; Lee, Kun Song ; Kim, Chun Soo ; Park, Su Eun ; Kim, Young Mi ; Oh, Chi Eun ; Ma, Sang Hyuk ; Jo, Dae Sun ; Choi, Young Youn ; Lee, Hoan Jong. / Etiology of invasive bacterial infections in immunocompetent children in Korea (2006-2010) : A retrospective multicenter study. In: Journal of Korean Medical Science. 2018 ; Vol. 33, No. 6.
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abstract = "Background: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. Methods: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005. Results: Escherichia coli (41.3{\%}), Streptococcus agalactiae (27.7{\%}), and Staphylococcus aureus (27.1{\%}) were the most common pathogens in infants < 3 months of age. S. agalactiae was the most prevalent cause of meningitis and pneumonia and E. coli was the major cause of bacteremia without localizing signs in this group. In children 3 to 59 months of age, Streptococcus pneumoniae (54.2{\%}), S. aureus (20.5{\%}), and Salmonella spp. (14.4{\%}) were the most common pathogens. S. pneumoniae was the leading cause of pneumonia (86.0{\%}), meningitis (65.0{\%}), and bacteremia without localizing signs (49.0{\%}) in this group. In children ≥ 5 years of age, S. aureus (62.8{\%}) was the predominant pathogen, followed by Salmonella species (12.4{\%}) and S. pneumoniae (11.5{\%}). Salmonella species (43.0{\%}) was the most common cause of bacteremia without localizing signs in this group. The relative proportion of S. aureus increased significantly over the 15-year period (1996-2010) in children ≥ 3 months of age (P < 0.001), while that of Haemophilus influenzae decreased significantly in both < 3 months of age group (P = 0.036) and ≥ 3 months of age groups (P < 0.001). Conclusion: S. agalactiae, E. coli, S. pneumoniae, and S. aureus are common etiologic agents of invasive bacterial infections in Korean children.",
keywords = "Bacterial infections, Epidemiology, Escherichia coli, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae",
author = "Kyuyol Rhie and Choi, {Eun Hwa} and Cho, {Eun Young} and Jina Lee and Kang, {Jin Han} and Kim, {Dong Soo} and Kim, {Yae Jean} and Youngmin Ahn and Eun, {Byung Wook} and Oh, {Sung Hee} and Cha, {Sung Ho} and Hong, {Young Jin} and Kim, {Kwang Nam} and Kim, {Nam Hee} and Kim, {Yun Kyung} and Kim, {Jong Hyun} and Taekjin Lee and Kim, {Hwang Min} and Lee, {Kun Song} and Kim, {Chun Soo} and Park, {Su Eun} and Kim, {Young Mi} and Oh, {Chi Eun} and Ma, {Sang Hyuk} and Jo, {Dae Sun} and Choi, {Young Youn} and Lee, {Hoan Jong}",
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TY - JOUR

T1 - Etiology of invasive bacterial infections in immunocompetent children in Korea (2006-2010)

T2 - A retrospective multicenter study

AU - Rhie, Kyuyol

AU - Choi, Eun Hwa

AU - Cho, Eun Young

AU - Lee, Jina

AU - Kang, Jin Han

AU - Kim, Dong Soo

AU - Kim, Yae Jean

AU - Ahn, Youngmin

AU - Eun, Byung Wook

AU - Oh, Sung Hee

AU - Cha, Sung Ho

AU - Hong, Young Jin

AU - Kim, Kwang Nam

AU - Kim, Nam Hee

AU - Kim, Yun Kyung

AU - Kim, Jong Hyun

AU - Lee, Taekjin

AU - Kim, Hwang Min

AU - Lee, Kun Song

AU - Kim, Chun Soo

AU - Park, Su Eun

AU - Kim, Young Mi

AU - Oh, Chi Eun

AU - Ma, Sang Hyuk

AU - Jo, Dae Sun

AU - Choi, Young Youn

AU - Lee, Hoan Jong

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. Methods: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005. Results: Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age. S. agalactiae was the most prevalent cause of meningitis and pneumonia and E. coli was the major cause of bacteremia without localizing signs in this group. In children 3 to 59 months of age, Streptococcus pneumoniae (54.2%), S. aureus (20.5%), and Salmonella spp. (14.4%) were the most common pathogens. S. pneumoniae was the leading cause of pneumonia (86.0%), meningitis (65.0%), and bacteremia without localizing signs (49.0%) in this group. In children ≥ 5 years of age, S. aureus (62.8%) was the predominant pathogen, followed by Salmonella species (12.4%) and S. pneumoniae (11.5%). Salmonella species (43.0%) was the most common cause of bacteremia without localizing signs in this group. The relative proportion of S. aureus increased significantly over the 15-year period (1996-2010) in children ≥ 3 months of age (P < 0.001), while that of Haemophilus influenzae decreased significantly in both < 3 months of age group (P = 0.036) and ≥ 3 months of age groups (P < 0.001). Conclusion: S. agalactiae, E. coli, S. pneumoniae, and S. aureus are common etiologic agents of invasive bacterial infections in Korean children.

AB - Background: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. Methods: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005. Results: Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age. S. agalactiae was the most prevalent cause of meningitis and pneumonia and E. coli was the major cause of bacteremia without localizing signs in this group. In children 3 to 59 months of age, Streptococcus pneumoniae (54.2%), S. aureus (20.5%), and Salmonella spp. (14.4%) were the most common pathogens. S. pneumoniae was the leading cause of pneumonia (86.0%), meningitis (65.0%), and bacteremia without localizing signs (49.0%) in this group. In children ≥ 5 years of age, S. aureus (62.8%) was the predominant pathogen, followed by Salmonella species (12.4%) and S. pneumoniae (11.5%). Salmonella species (43.0%) was the most common cause of bacteremia without localizing signs in this group. The relative proportion of S. aureus increased significantly over the 15-year period (1996-2010) in children ≥ 3 months of age (P < 0.001), while that of Haemophilus influenzae decreased significantly in both < 3 months of age group (P = 0.036) and ≥ 3 months of age groups (P < 0.001). Conclusion: S. agalactiae, E. coli, S. pneumoniae, and S. aureus are common etiologic agents of invasive bacterial infections in Korean children.

KW - Bacterial infections

KW - Epidemiology

KW - Escherichia coli

KW - Staphylococcus aureus

KW - Streptococcus agalactiae

KW - Streptococcus pneumoniae

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DO - 10.3346/jkms.2018.33.e45

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