Eucalyptol and its role in chronic diseases

Geun Hee Seol, Ka Young Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Patients with chronic diseases such as cardiovascular diseases, chronic respiratory diseases, and neurological diseases have been shown to benefit from treatments such as aromatherapy in addition to medication. Most chronic diseases are caused by chronic inflammation and oxidative stress as well as harmful factors. Eucalyptol (1,8-cineole), a terpenoid oxide isolated from Eucalyptus species, is a promising compound for treating such conditions as it has been shown to have anti-inflammatory and antioxidant effects in various diseases, including respiratory disease, pancreatitis, colon damage, and cardiovascular and neurodegenerative diseases. Eucalyptol suppresses lipopolysaccharide (LPS)-induced proinflammatory cytokine production through the action of NF-κB, TNF-α, IL-1β, and IL-6 and the extracellular signal-regulated kinase (ERK) pathway, and reduces oxidative stress through the regulation of signaling pathways and radical scavenging. The effects of eucalyptol have been studied in several cell and animal models as well as in patients with chronic diseases. Furthermore, eucalyptol can pass the blood-brain barrier and hence can be used as a carrier to deliver drugs to the brain via a microemulsion system. In summary, the various biological activities of eucalyptol such as its anti-inflammatory and antioxidant properties, as well as its physicochemical characteristics, make this compound a potentially important drug for the treatment of chronic diseases.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages389-398
Number of pages10
Volume929
DOIs
Publication statusPublished - 2016 Oct 1

Publication series

NameAdvances in Experimental Medicine and Biology
Volume929
ISSN (Print)00652598
ISSN (Electronic)22148019

Fingerprint

Chronic Disease
Pulmonary diseases
Oxidative stress
Oxidative Stress
Anti-Inflammatory Agents
Cardiovascular Diseases
Antioxidants
Aromatherapy
Neurodegenerative diseases
Eucalyptus
Scavenging
Terpenes
Extracellular Signal-Regulated MAP Kinases
Microemulsions
Bioactivity
Blood-Brain Barrier
Interleukin-1
Neurodegenerative Diseases
Pharmaceutical Preparations
Pancreatitis

Keywords

  • Anti-inflammatory
  • Antioxidant
  • Chronic disease
  • Eucalyptol

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Seol, G. H., & Kim, K. Y. (2016). Eucalyptol and its role in chronic diseases. In Advances in Experimental Medicine and Biology (Vol. 929, pp. 389-398). (Advances in Experimental Medicine and Biology; Vol. 929). Springer New York LLC. https://doi.org/10.1007/978-3-319-41342-6_18

Eucalyptol and its role in chronic diseases. / Seol, Geun Hee; Kim, Ka Young.

Advances in Experimental Medicine and Biology. Vol. 929 Springer New York LLC, 2016. p. 389-398 (Advances in Experimental Medicine and Biology; Vol. 929).

Research output: Chapter in Book/Report/Conference proceedingChapter

Seol, GH & Kim, KY 2016, Eucalyptol and its role in chronic diseases. in Advances in Experimental Medicine and Biology. vol. 929, Advances in Experimental Medicine and Biology, vol. 929, Springer New York LLC, pp. 389-398. https://doi.org/10.1007/978-3-319-41342-6_18
Seol GH, Kim KY. Eucalyptol and its role in chronic diseases. In Advances in Experimental Medicine and Biology. Vol. 929. Springer New York LLC. 2016. p. 389-398. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-41342-6_18
Seol, Geun Hee ; Kim, Ka Young. / Eucalyptol and its role in chronic diseases. Advances in Experimental Medicine and Biology. Vol. 929 Springer New York LLC, 2016. pp. 389-398 (Advances in Experimental Medicine and Biology).
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