EUS-guided irreversible electroporation using endoscopic needle-electrode in porcine pancreas

Jae Min Lee, Hyuk Soon Choi, Hoon Jai Chun, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Soon Ho Um, Chang Duck Kim, Hong Bae Kim

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background: Endoscopic irreversible electroporation (IRE) can be performed using a flexible, thin, needle-shaped electrode for an endoscopic ultrasound (EUS)-guided procedure. This study aimed to evaluate the feasibility and efficacy of performing EUS-guided IRE with endoscopic needle-electrode in porcine pancreas. Methods: Experimental endoscopic IRE on the pancreas were performed by EUS-guided approach in three pigs and compared with surgical approach in three pigs. The animals were killed after 24 h and their pancreases collected. Results: IRE ablation using endoscopic needle-electrode was successful technically in EUS-guided approaches for the pancreas. Immediately following IRE, the ablated pancreatic tissue showed no gross change except focal hemorrhage. H&E staining presented a well-demarcated ablation site measuring 1.0–1.5 cm in diameter in the pancreas. TUNEL immunohistochemistry showed diffuse cell death along the puncture site 24 h after IRE. No complication was observed in pigs after endoscopic IRE ablation. Conclusion: EUS-guided IRE ablation was feasible and effective for pancreas using the newly developed device.

Original languageEnglish
Pages (from-to)658-662
Number of pages5
JournalSurgical Endoscopy
Volume33
Issue number2
DOIs
Publication statusPublished - 2019 Feb 15

Keywords

  • Animal
  • EUS
  • Endoscopy
  • Irreversible electroporation
  • Pancreas

ASJC Scopus subject areas

  • Surgery

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