Evaluation of a rapid diagnostic test specific for Plasmodium vivax

Sun Hyung Kim, Myung-Hyun Nam, Kyoung Ho Roh, Hae Chul Park, Deok Hwa Nam, Gil-Hong Park, Eun Taek Han, Terry A. Klein, Chae Seung Lim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Plasmodium vivax is the only human malaria indigenous to the Republic of Korea (ROK). A rapid and sensitive diagnostic test (RDT) that detects P. vivax is appropriate for evaluating suspected malaria patients with no travel history abroad. The RDTs, SD Malaria Antigen P.v (SD diagnostic, Kyonggi, ROK) specific for P. vivax and the well documented OptiMAL (DiaMed, Cressier, Switzerland) were compared among 282 volunteers for specificity and sensitivity of P. vivax and Plasmodium falciparum malaria infections against Giemsa-stained blood smears read by an experienced microscopist. A total of 137 volunteers were diagnosed with P. vivax, 45 cases (returned travellers from overseas) were diagnosed with P. falciparum and 100 healthy volunteers were diagnosed as negative for malaria. Correspondingly, the SD Malaria Antigen P.v test identified P. vivax infections in 128/137 malaria patients (93.4%) and 0/100 (0%) healthy volunteers. Three patients identified with P. falciparum also were interpreted as P. vivax by the SD Malaria Antigen P.v test; however, these patients were later confirmed as mixed infections of P. vivax and P. falciparum by polymerase chain reaction. OptiMAL interpreted the three mixed infections only as P. falciparum and detected 130/137 (94.9%) patients with P. vivax. The sensitivity of the SD Malaria Antigen P.v test decreased from 100% (>5000 parasite/μl) to 81.3% (1-100 parasites/μl) as parasitaemia levels declined. For the regions where P. vivax is the primary malaria parasite, the SD P. vivax-specific rapid diagnostic test may be useful for screening suspected malaria patients when sufficient material and human resources (e.g. trained microscopists) are unavailable for malaria diagnosis.

Original languageEnglish
Pages (from-to)1495-1500
Number of pages6
JournalTropical Medicine and International Health
Volume13
Issue number12
DOIs
Publication statusPublished - 2008 Dec 1

Fingerprint

Plasmodium vivax
Routine Diagnostic Tests
Malaria
Histocompatibility Antigens
Plasmodium falciparum
Republic of Korea
Parasites
Coinfection
Volunteers
Healthy Volunteers
Vivax Malaria
Parasitemia
Falciparum Malaria
Switzerland

Keywords

  • OptiMAL
  • Parasite lactate dehydrogenase
  • Plasmodium vivax
  • SD Malaria Antigen P.v

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Parasitology

Cite this

Evaluation of a rapid diagnostic test specific for Plasmodium vivax. / Kim, Sun Hyung; Nam, Myung-Hyun; Roh, Kyoung Ho; Park, Hae Chul; Nam, Deok Hwa; Park, Gil-Hong; Han, Eun Taek; Klein, Terry A.; Lim, Chae Seung.

In: Tropical Medicine and International Health, Vol. 13, No. 12, 01.12.2008, p. 1495-1500.

Research output: Contribution to journalArticle

Kim, Sun Hyung ; Nam, Myung-Hyun ; Roh, Kyoung Ho ; Park, Hae Chul ; Nam, Deok Hwa ; Park, Gil-Hong ; Han, Eun Taek ; Klein, Terry A. ; Lim, Chae Seung. / Evaluation of a rapid diagnostic test specific for Plasmodium vivax. In: Tropical Medicine and International Health. 2008 ; Vol. 13, No. 12. pp. 1495-1500.
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