Evaluation of a urinary test as a diagnostic tool of a nonprogressive pregnancy

Silhem Mazouz, Jae Kwan Lee, Hervé Fernandez

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To evaluate the performance of a one-step test detecting intact hCG and free β-hCG isoforms in the urine of pregnant women to diagnose an abnormal pregnancy. Design: Prospective study. Setting: Emergency gynecology departments in teaching hospitals. Patient(s): Five hundred twenty-six patients were enrolled, 272 who were not pregnant and 254 who were pregnant. Intervention(s) and Main Outcome Measure(s): Semiquantitative determination of intact urinary hCG of supposedly not pregnant and pregnant women with vaginal bleeding and/or vaginal pain between 5 and 8 weeks of amenorrhea. Result(s): The sensitivity and specificity of the urine test for diagnosing nonpregnancy were, respectively, 100% (252/252) and 100% (272/272). The sensitivity and specificity of the urine test for diagnosing ectopic pregnancy (EP) were, respectively, 97% (32/33) and 83% (142/171). The negative predictive value is 99.3% (142/143). The sensitivity and specificity or the urine test for diagnosing miscarriage were, respectively, 89.6% (43/48) and 83% (142/171). The negative predictive value is 96.6% (142/147). Conclusion(s): Abnormal pregnancy, such as an EP or a miscarriage, can be rapidly detected with the one-step test for intact hCG and free β-hCG isoforms. If ultrasound cannot confirm the localization and/or evolution of a pregnancy, using this test reduces medical supervision and repeated quantification of hCG.

Original languageEnglish
Pages (from-to)783-786
Number of pages4
JournalFertility and Sterility
Volume95
Issue number2
DOIs
Publication statusPublished - 2011 Feb 1

Fingerprint

Urine
Pregnancy
Ectopic Pregnancy
Spontaneous Abortion
Exercise Test
Sensitivity and Specificity
Pregnant Women
Protein Isoforms
Pregnancy Tests
Uterine Hemorrhage
Amenorrhea
Gynecology
Teaching Hospitals
Hospital Emergency Service
Outcome Assessment (Health Care)
Prospective Studies
Pain

Keywords

  • Abnormal pregnancy
  • ectopic pregnancy
  • free β-hCG
  • hCG
  • intact hCG
  • miscarriage
  • urine test

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Evaluation of a urinary test as a diagnostic tool of a nonprogressive pregnancy. / Mazouz, Silhem; Lee, Jae Kwan; Fernandez, Hervé.

In: Fertility and Sterility, Vol. 95, No. 2, 01.02.2011, p. 783-786.

Research output: Contribution to journalArticle

Mazouz, Silhem ; Lee, Jae Kwan ; Fernandez, Hervé. / Evaluation of a urinary test as a diagnostic tool of a nonprogressive pregnancy. In: Fertility and Sterility. 2011 ; Vol. 95, No. 2. pp. 783-786.
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