Evaluation of a urinary test as a diagnostic tool of a nonprogressive pregnancy

Silhem Mazouz, Jae Kwan Lee, Hervé Fernandez

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To evaluate the performance of a one-step test detecting intact hCG and free β-hCG isoforms in the urine of pregnant women to diagnose an abnormal pregnancy. Design: Prospective study. Setting: Emergency gynecology departments in teaching hospitals. Patient(s): Five hundred twenty-six patients were enrolled, 272 who were not pregnant and 254 who were pregnant. Intervention(s) and Main Outcome Measure(s): Semiquantitative determination of intact urinary hCG of supposedly not pregnant and pregnant women with vaginal bleeding and/or vaginal pain between 5 and 8 weeks of amenorrhea. Result(s): The sensitivity and specificity of the urine test for diagnosing nonpregnancy were, respectively, 100% (252/252) and 100% (272/272). The sensitivity and specificity of the urine test for diagnosing ectopic pregnancy (EP) were, respectively, 97% (32/33) and 83% (142/171). The negative predictive value is 99.3% (142/143). The sensitivity and specificity or the urine test for diagnosing miscarriage were, respectively, 89.6% (43/48) and 83% (142/171). The negative predictive value is 96.6% (142/147). Conclusion(s): Abnormal pregnancy, such as an EP or a miscarriage, can be rapidly detected with the one-step test for intact hCG and free β-hCG isoforms. If ultrasound cannot confirm the localization and/or evolution of a pregnancy, using this test reduces medical supervision and repeated quantification of hCG.

Original languageEnglish
Pages (from-to)783-786
Number of pages4
JournalFertility and Sterility
Volume95
Issue number2
DOIs
Publication statusPublished - 2011 Feb

Keywords

  • Abnormal pregnancy
  • ectopic pregnancy
  • free β-hCG
  • hCG
  • intact hCG
  • miscarriage
  • urine test

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Evaluation of a urinary test as a diagnostic tool of a nonprogressive pregnancy'. Together they form a unique fingerprint.

  • Cite this