Evaluation of acid-treated hyaluronic acid-based hydrogelation

Mi Sook Kim; Yoon Jeong Choi; Gun Woo Kim; Insup Non; Yongdoo Park; Kyu Back Lee; In Sook Kim; Soon Jung Hwang

doi:10.4028/0-87849-436-7.745

Evaluation of acid-treated hyaluronic acid-based hydrogelation

Mi Sook Kim, Yoon Jeong Choi, Gun Woo Kim, Insup Non, Yongdoo Park, Kyu Back Lee, In Sook Kim, Soon Jung Hwang

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedical society, it's long molecular weights sometimes have been problematic due to its difficulty in handling. After reduction of its high molecular weight into smaller sizes with various concentrations of hydrogen chloride solutions, its chemical and biological properties have been examined by changes in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellular interactions. While FTIR analysis indicated maintenance of its original chemical structures, its viscosity has been remarkably reduced and its extent was dependent upon the employment of acid concentrations. After controlling its molecular weight to approximately 100 kDa and coupling of aminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cell proliferations of the HA-poly(ethylene oxide) (PEO) hydrogel.

Original language	English
Pages (from-to)	745-748
Number of pages	4
Journal	Key Engineering Materials
Volume	342-343
DOIs	https://doi.org/10.4028/0-87849-436-7.745
Publication status	Published - 2007

Keywords

Evaluation
Hyaluronic acid
In situ hydrogel
Molecular weight
Poly(ethylene oxide)

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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Kim, M. S., Choi, Y. J., Kim, G. W., Non, I., Park, Y., Lee, K. B., Kim, I. S., & Hwang, S. J. (2007). Evaluation of acid-treated hyaluronic acid-based hydrogelation. Key Engineering Materials, 342-343, 745-748. https://doi.org/10.4028/0-87849-436-7.745

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AU - Park, Yongdoo

AU - Lee, Kyu Back

AU - Kim, In Sook

AU - Hwang, Soon Jung

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AB - Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedical society, it's long molecular weights sometimes have been problematic due to its difficulty in handling. After reduction of its high molecular weight into smaller sizes with various concentrations of hydrogen chloride solutions, its chemical and biological properties have been examined by changes in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellular interactions. While FTIR analysis indicated maintenance of its original chemical structures, its viscosity has been remarkably reduced and its extent was dependent upon the employment of acid concentrations. After controlling its molecular weight to approximately 100 kDa and coupling of aminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cell proliferations of the HA-poly(ethylene oxide) (PEO) hydrogel.

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