Evaluation of acid-treated hyaluronic acid-based hydrogelation

Mi Sook Kim; Yoon Jeong Choi; Gun Woo Kim; Insup Non; Yongdoo Park; Kyu Back Lee; In Sook Kim; Soon Jung Hwang

doi:10.4028/0-87849-436-7.745

Evaluation of acid-treated hyaluronic acid-based hydrogelation

Mi Sook Kim, Yoon Jeong Choi, Gun Woo Kim, Insup Non, Yongdoo Park, Kyu Back Lee, In Sook Kim, Soon Jung Hwang

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedical society, it's long molecular weights sometimes have been problematic due to its difficulty in handling. After reduction of its high molecular weight into smaller sizes with various concentrations of hydrogen chloride solutions, its chemical and biological properties have been examined by changes in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellular interactions. While FTIR analysis indicated maintenance of its original chemical structures, its viscosity has been remarkably reduced and its extent was dependent upon the employment of acid concentrations. After controlling its molecular weight to approximately 100 kDa and coupling of aminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cell proliferations of the HA-poly(ethylene oxide) (PEO) hydrogel.

Original language	English
Pages (from-to)	745-748
Number of pages	4
Journal	Key Engineering Materials
Volume	342-343
DOIs	https://doi.org/10.4028/0-87849-436-7.745
Publication status	Published - 2007

Keywords

Evaluation
Hyaluronic acid
In situ hydrogel
Molecular weight
Poly(ethylene oxide)

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

Access to Document

10.4028/0-87849-436-7.745

Cite this

@article{42c8f4db8dfb4003b2000d5b463ac93c,

title = "Evaluation of acid-treated hyaluronic acid-based hydrogelation",

abstract = "Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedical society, it's long molecular weights sometimes have been problematic due to its difficulty in handling. After reduction of its high molecular weight into smaller sizes with various concentrations of hydrogen chloride solutions, its chemical and biological properties have been examined by changes in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellular interactions. While FTIR analysis indicated maintenance of its original chemical structures, its viscosity has been remarkably reduced and its extent was dependent upon the employment of acid concentrations. After controlling its molecular weight to approximately 100 kDa and coupling of aminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cell proliferations of the HA-poly(ethylene oxide) (PEO) hydrogel.",

keywords = "Evaluation, Hyaluronic acid, In situ hydrogel, Molecular weight, Poly(ethylene oxide)",

author = "Kim, {Mi Sook} and Choi, {Yoon Jeong} and Kim, {Gun Woo} and Insup Non and Yongdoo Park and Lee, {Kyu Back} and Kim, {In Sook} and Hwang, {Soon Jung}",

note = "Funding Information: The authors express their gratitude to Dr. Scott Stauffer of University of Dayton Research Institute for stimulating scientific discussions and technical assistance. The authors would like to thank Richard Zehring of Innovative Scientific Solutions, Inc. for his excellent assistance with the combustion facility. This work was funded by the Air Force Research Laboratory contract nos. FA8650-12-C-2236 and FA8650-15-D-2518 and by the Air Force Office of Scientific Research (14RQ06COR) (Dr. Chiping Li, Program Officer). This work was cleared for public release (88ABW-2015-4424).",

year = "2007",

doi = "10.4028/0-87849-436-7.745",

language = "English",

volume = "342-343",

pages = "745--748",

journal = "Key Engineering Materials",

issn = "1013-9826",

publisher = "Trans Tech Publications",

}

TY - JOUR

T1 - Evaluation of acid-treated hyaluronic acid-based hydrogelation

AU - Kim, Mi Sook

AU - Choi, Yoon Jeong

AU - Kim, Gun Woo

AU - Non, Insup

AU - Park, Yongdoo

AU - Lee, Kyu Back

AU - Kim, In Sook

AU - Hwang, Soon Jung

N1 - Funding Information: The authors express their gratitude to Dr. Scott Stauffer of University of Dayton Research Institute for stimulating scientific discussions and technical assistance. The authors would like to thank Richard Zehring of Innovative Scientific Solutions, Inc. for his excellent assistance with the combustion facility. This work was funded by the Air Force Research Laboratory contract nos. FA8650-12-C-2236 and FA8650-15-D-2518 and by the Air Force Office of Scientific Research (14RQ06COR) (Dr. Chiping Li, Program Officer). This work was cleared for public release (88ABW-2015-4424).

PY - 2007

Y1 - 2007

N2 - Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedical society, it's long molecular weights sometimes have been problematic due to its difficulty in handling. After reduction of its high molecular weight into smaller sizes with various concentrations of hydrogen chloride solutions, its chemical and biological properties have been examined by changes in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellular interactions. While FTIR analysis indicated maintenance of its original chemical structures, its viscosity has been remarkably reduced and its extent was dependent upon the employment of acid concentrations. After controlling its molecular weight to approximately 100 kDa and coupling of aminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cell proliferations of the HA-poly(ethylene oxide) (PEO) hydrogel.

AB - Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedical society, it's long molecular weights sometimes have been problematic due to its difficulty in handling. After reduction of its high molecular weight into smaller sizes with various concentrations of hydrogen chloride solutions, its chemical and biological properties have been examined by changes in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellular interactions. While FTIR analysis indicated maintenance of its original chemical structures, its viscosity has been remarkably reduced and its extent was dependent upon the employment of acid concentrations. After controlling its molecular weight to approximately 100 kDa and coupling of aminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cell proliferations of the HA-poly(ethylene oxide) (PEO) hydrogel.

KW - Evaluation

KW - Hyaluronic acid

KW - In situ hydrogel

KW - Molecular weight

KW - Poly(ethylene oxide)

UR - http://www.scopus.com/inward/record.url?scp=34147132894&partnerID=8YFLogxK

U2 - 10.4028/0-87849-436-7.745

DO - 10.4028/0-87849-436-7.745

M3 - Article

AN - SCOPUS:34147132894

VL - 342-343

SP - 745

EP - 748

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

ER -

Evaluation of acid-treated hyaluronic acid-based hydrogelation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this