Evaluation of acid-treated hyaluronic acid-based hydrogelation

Mi Sook Kim, Yoon Jeong Choi, Gun Woo Kim, Insup Non, Yongdoo Park, Kyu Back Lee, In Sook Kim, Soon Jung Hwang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedical society, it's long molecular weights sometimes have been problematic due to its difficulty in handling. After reduction of its high molecular weight into smaller sizes with various concentrations of hydrogen chloride solutions, its chemical and biological properties have been examined by changes in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellular interactions. While FTIR analysis indicated maintenance of its original chemical structures, its viscosity has been remarkably reduced and its extent was dependent upon the employment of acid concentrations. After controlling its molecular weight to approximately 100 kDa and coupling of aminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cell proliferations of the HA-poly(ethylene oxide) (PEO) hydrogel.

Original languageEnglish
Pages (from-to)745-748
Number of pages4
JournalKey Engineering Materials
Volume342-343
Publication statusPublished - 2007 Apr 16

Fingerprint

Hyaluronic acid
Hyaluronic Acid
Hydrogel
Molecular weight
Polyethylene oxides
Hydrogels
Acids
Viscosity
Hydrochloric Acid
Cell proliferation
Gel permeation chromatography
Spectroscopy
Hydrogen

Keywords

  • Evaluation
  • Hyaluronic acid
  • In situ hydrogel
  • Molecular weight
  • Poly(ethylene oxide)

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Kim, M. S., Choi, Y. J., Kim, G. W., Non, I., Park, Y., Lee, K. B., ... Hwang, S. J. (2007). Evaluation of acid-treated hyaluronic acid-based hydrogelation. Key Engineering Materials, 342-343, 745-748.

Evaluation of acid-treated hyaluronic acid-based hydrogelation. / Kim, Mi Sook; Choi, Yoon Jeong; Kim, Gun Woo; Non, Insup; Park, Yongdoo; Lee, Kyu Back; Kim, In Sook; Hwang, Soon Jung.

In: Key Engineering Materials, Vol. 342-343, 16.04.2007, p. 745-748.

Research output: Contribution to journalArticle

Kim, MS, Choi, YJ, Kim, GW, Non, I, Park, Y, Lee, KB, Kim, IS & Hwang, SJ 2007, 'Evaluation of acid-treated hyaluronic acid-based hydrogelation', Key Engineering Materials, vol. 342-343, pp. 745-748.
Kim MS, Choi YJ, Kim GW, Non I, Park Y, Lee KB et al. Evaluation of acid-treated hyaluronic acid-based hydrogelation. Key Engineering Materials. 2007 Apr 16;342-343:745-748.
Kim, Mi Sook ; Choi, Yoon Jeong ; Kim, Gun Woo ; Non, Insup ; Park, Yongdoo ; Lee, Kyu Back ; Kim, In Sook ; Hwang, Soon Jung. / Evaluation of acid-treated hyaluronic acid-based hydrogelation. In: Key Engineering Materials. 2007 ; Vol. 342-343. pp. 745-748.
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