Abstract
Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedical society, it's long molecular weights sometimes have been problematic due to its difficulty in handling. After reduction of its high molecular weight into smaller sizes with various concentrations of hydrogen chloride solutions, its chemical and biological properties have been examined by changes in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellular interactions. While FTIR analysis indicated maintenance of its original chemical structures, its viscosity has been remarkably reduced and its extent was dependent upon the employment of acid concentrations. After controlling its molecular weight to approximately 100 kDa and coupling of aminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cell proliferations of the HA-poly(ethylene oxide) (PEO) hydrogel.
| Original language | English |
|---|---|
| Pages (from-to) | 745-748 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 342-343 |
| Publication status | Published - 2007 Apr 16 |
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Keywords
- Evaluation
- Hyaluronic acid
- In situ hydrogel
- Molecular weight
- Poly(ethylene oxide)
ASJC Scopus subject areas
- Ceramics and Composites
- Chemical Engineering (miscellaneous)
Cite this
Evaluation of acid-treated hyaluronic acid-based hydrogelation. / Kim, Mi Sook; Choi, Yoon Jeong; Kim, Gun Woo; Non, Insup; Park, Yongdoo; Lee, Kyu Back; Kim, In Sook; Hwang, Soon Jung.
In: Key Engineering Materials, Vol. 342-343, 16.04.2007, p. 745-748.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of acid-treated hyaluronic acid-based hydrogelation
AU - Kim, Mi Sook
AU - Choi, Yoon Jeong
AU - Kim, Gun Woo
AU - Non, Insup
AU - Park, Yongdoo
AU - Lee, Kyu Back
AU - Kim, In Sook
AU - Hwang, Soon Jung
PY - 2007/4/16
Y1 - 2007/4/16
N2 - Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedical society, it's long molecular weights sometimes have been problematic due to its difficulty in handling. After reduction of its high molecular weight into smaller sizes with various concentrations of hydrogen chloride solutions, its chemical and biological properties have been examined by changes in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellular interactions. While FTIR analysis indicated maintenance of its original chemical structures, its viscosity has been remarkably reduced and its extent was dependent upon the employment of acid concentrations. After controlling its molecular weight to approximately 100 kDa and coupling of aminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cell proliferations of the HA-poly(ethylene oxide) (PEO) hydrogel.
AB - Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedical society, it's long molecular weights sometimes have been problematic due to its difficulty in handling. After reduction of its high molecular weight into smaller sizes with various concentrations of hydrogen chloride solutions, its chemical and biological properties have been examined by changes in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellular interactions. While FTIR analysis indicated maintenance of its original chemical structures, its viscosity has been remarkably reduced and its extent was dependent upon the employment of acid concentrations. After controlling its molecular weight to approximately 100 kDa and coupling of aminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cell proliferations of the HA-poly(ethylene oxide) (PEO) hydrogel.
KW - Evaluation
KW - Hyaluronic acid
KW - In situ hydrogel
KW - Molecular weight
KW - Poly(ethylene oxide)
UR - http://www.scopus.com/inward/record.url?scp=34147132894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34147132894&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:34147132894
VL - 342-343
SP - 745
EP - 748
JO - Key Engineering Materials
JF - Key Engineering Materials
SN - 1013-9826
ER -