Evaluation of brain-blood barrier permeable peptide using microfluidic reconstituted BBB model

Bohye Chung, Jaehoon Kim, Hyunho Kim, Hyun Jeong Oh, Seok Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The Blood-brain barrier (BBB) is a selective barrier blocking the passage of most molecules for the central nervous system (CNS). Because of unique function of blood-brain barrier, the development of therapeutic drugs for brain diseases and evaluating of the CNS drug candidates has been interrupted. To develop a useful in vitro BBB model, we constructed a microfluidic BBB model. We compared the permeability value of hCMEC/D3 monolayer with hMVEC monolayer. Furthermore, we applied a cell-penetrating peptide, Angiopep-2, to our BBB platform. The higher permeability value of Angiopep-2 than same sized dextran molecule was proved in BBB device.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages1601-1603
Number of pages3
ISBN (Electronic)9781510897571
Publication statusPublished - 2018 Jan 1
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: 2018 Nov 112018 Nov 15

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume3

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period18/11/1118/11/15

Keywords

  • Brain-blood barrier
  • Cell penetrating peptide
  • Microfluidics

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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  • Cite this

    Chung, B., Kim, J., Kim, H., Oh, H. J., & Chung, S. (2018). Evaluation of brain-blood barrier permeable peptide using microfluidic reconstituted BBB model. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 1601-1603). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 3). Chemical and Biological Microsystems Society.