Evaluation of ceftriaxone utilization at multicenter study

Hyuck Lee, Dongsik Jung, Joon Sup Yeom, Jun Seong Son, Sook In Jung, Yeon Sook Kim, Chun Kwan Kim, Hyun Ha Chang, Shin Woo Kim, Hyun Kyun Ki, Chi Sook Moon, Doo Ryeon Chung, Kyong Ran Peck, Jae Hoon Song, Gun Jo Woo

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Background/Aims: As bacterial resistance to antimicrobial agents has grown due to the increasing use of antimicrobial agents, we sought to evaluate the suitability of ceftriaxone usage (representative of third generation cephalosporins) at 10 university hospitals in Korea. Methods: We prospectively evaluated the appropriateness of antibiotic usage in 400 adult patients who received ceftriaxone between February 1, 2006 and June 30, 2006. Drug utilization evaluation (DUE) methods were based on standards set forth by the American Society of Hospital Pharmacists. The DUE criteria used in this study were modified to be more suitable in our hospital setting: justification of drug use, critical and process indications, complications, and outcome measures. Results: The average patient age was 64.4 years. The utilization of ceftriaxone was appropriate in 262 cases (65.5%) for the justification of use, while inappropriate use was observed in 138 cases (34.5%). Common reasons for inappropriate use of ceftriaxone included continued empiric use for presumed infections, prophylactic perioperative injection, and empiric therapy for fever. Most of the critical indications showed a high rate of suitability (66.5-98.5%). Complications occurred in 37 cases (9.3%). With respect to outcome measures, clinical responses were observed in 60.7% of cases, while only 15.7% of cases showed evidence of infection eradication via negative cultures. Conclusions: Appropriate use (65.5%) of ceftriaxone was higher than inappropriate use (34.5%) at university hospitals in Korea. Inappropriate utilization, however, including continued empiric use for presumed infections and prophylactic perioperative injection remained high. Intensification of educational programs and antibiotic control systems for ceftriaxone is needed to improve the suitability of antimicrobial use.

Original languageEnglish
Pages (from-to)374-380
Number of pages7
JournalKorean Journal of Internal Medicine
Issue number4
Publication statusPublished - 2009


  • Ceftriaxone
  • Drug utilization review

ASJC Scopus subject areas

  • Internal Medicine


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