Evaluation of chemical interactions between small molecules in the gas phase using chemical force microscopy

Jieun Lee, Soomi Ju, In Tae Kim, Sun Hwa Jung, Sun Joon Min, Chulki Kim, Sang Jun Sim, Sang Kyung Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Chemical force microscopy analyzes the interactions between various chemical/biochemical moieties in situ. In this work we examined force-distance curves and lateral force to measure the interaction between modified AFM tips and differently functionalized molecular monolayers. Especially for the measurements in gas phase, we investigated the effect of humidity on the analysis of force-distance curves and the images in lateral force mode. Flat chemical patterns composed of different functional groups were made through micro-contact printing and lateral force mode provided more resolved analysis of the chemical patterns. From the images of 1-octadecanethiol/11-mercapto-1-undecanoic acid patterns, the amine group functionalized tip brought out higher contrast of the patterns than an intact silicon nitride tip owing to the additional chemical interaction between carboxyl and amine groups. For more complex chemical interactions, relative chemical affinities toward specific peptides were assessed on the pattern of 1-octadecanethiol/phenyl-terminated alkanethiol. The lateral image of chemical force microscopy reflected specific preference of a peptide to phenyl group as well as the hydrophobic interaction.

Original languageEnglish
Pages (from-to)30683-30692
Number of pages10
JournalSensors (Switzerland)
Volume15
Issue number12
DOIs
Publication statusPublished - 2015 Dec 4

Keywords

  • Benzene specific peptide
  • Chemical force microscopy
  • Lateral force image
  • Micro-contact printing

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics
  • Analytical Chemistry
  • Biochemistry

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