Evaluation of clinical risk factors for developing pleural empyema secondary to liver abscess

Eunjue Yi, Tae Hyung Kim, Jun Hee Lee, Jae Ho Chung, Sungho Lee

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: The aim of this study was to investigate the clinical manifestation and predictive risk factors of pleural empyema developing during treatment of the pyogenic liver abscess. Methods: Medical records of patients with the liver abscess in our institution were reviewed retrospectively. Enrolled patients were classified into four groups; Group 1: patients without pleural effusion, Group 2: patients with pleural effusion and who were treated noninvasively, Group 3: patient with pleural effusion and who were treated with thoracentesis, and Group 4: patients with pleural effusion that developed into empyema. Patient characteristics, clinical manifestation, and possible risk factors in development of empyema were analyzed. Results: A total of 234 patients was enrolled in this study. The incidence rate of empyema was 4.27% (10 patients). The mean interval for developing pleural effusion was 5.6 ± 6.35 days. In multivariate analysis, risk factors for developing pleural effusion included the location of the liver abscess near the right diaphragm (segment 7 and 8, OR = 2.30, p = 0.048), and larger diameter of the liver abscess (OR = 1.02, p = 0.042). Among patients who developed pleural effusions, presences of mixed microorganisms from culture of liver aspirates (OR = 10.62, p = 0.044), bilateral pleural effusion (OR = 46.72, p = 0.012) and combined biliary tract inflammation (OR = 21.05, p = 0.040) were significantly associated with the need for invasive intervention including surgery on effusion. Conclusion: The location of the liver abscess as well as pleural effusion, elevated inflammatory markers, and combined biliary tract inflammation may be important markers of developing pleural complication in patients with pyogenic liver abscess.

    Original languageEnglish
    Article number215
    JournalBMC Gastroenterology
    Volume19
    Issue number1
    DOIs
    Publication statusPublished - 2019 Dec 16

    Keywords

    • Liver abscess
    • Pleural empyema
    • Risk factors

    ASJC Scopus subject areas

    • Gastroenterology

    Fingerprint

    Dive into the research topics of 'Evaluation of clinical risk factors for developing pleural empyema secondary to liver abscess'. Together they form a unique fingerprint.

    Cite this