Evaluation of extracellular volume fraction thresholds corresponding to myocardial late-gadolinium enhancement using cardiac magnetic resonance

Sung Ho Hwang, Eui Young Choi, Chul Hwan Park, Mun Young Paek, Andreas Greiser, Tae Hoon Kim, Byoung Wook Choi

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4 Citations (Scopus)


To establish extracellular volume fraction (ECV) thresholds corresponding to myocardial lesion detected by late-gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging. Fifty-six patients with myocardial infarction or hypertrophic cardiomyopathy underwent LGE, pre- and post-contrast modified Look-Locker inversion recovery (MOLLI) sequences on a 3-T CMR system. Short-axis MOLLI images generated ECV maps of left ventricular (LV) walls. The LGE areas were semi-automatically determined by different signal threshold techniques. The areas of elevated ECV were measured using ECV thresholds of 28–48 %. The LGE areas were compared with the areas of elevated ECV at the corresponding LV levels. The myocardial areas of LGE and elevated ECVs showed a strong and positive correlation (P < 0.01). The LGE threshold, set at two standard deviations above the mean signal from the remote myocardium, corresponded well with the area of ECV >32 %. When using the full width at half-maximum (FWHM) technique, the LGE area corresponded well with the area of ECV >42 or 44 %. By applying particular ECV thresholds, myocardial ECV maps can define myocardial status equivalent to LGE, and definite ECV thresholds may be useful for the straightforward evaluation of myocardial phenotypes.

Original languageEnglish
Pages (from-to)137-144
Number of pages8
JournalInternational Journal of Cardiovascular Imaging
Issue number2
Publication statusPublished - 2014 Jan 1



  • Extracellular volume fraction
  • Late gadolinium enhancement
  • Magnetic resonance imaging
  • Myocardium
  • T1 relaxation time

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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