Evaluation of fluid warmer safety using hemorheologic analysis with outdated human blood

Hee Jung Kim, Sung Mook Yoo, Jae Ho Chung, Tae Sik Kim, Sung Ho Lee, Ho Sung Son

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

PURPOSE: A newly developed fluid warmer (ThermoSens®) has a direct blood warming plate, which can result in hemolysis or red blood cell injury during heating. Therefore, to evaluate the safety of heating blood products with a fluid warmer, we conducted laboratory tests to study hemolysis and erythrocyte rheology. METHODS: We used outdated human blood taken from a Korean blood bank. Packed red blood cells mixed with 100 mL isotonic saline was passed through the fluid warmer. Blood flow was achieved by either gravity or 300 mmHg pressure. Blood samples were analyzed before and after heating for hemolysis marker and erythrocyte rheology parameters. RESULTS: The temperatures at the outlet were higher than 38°C at gravity and 300 mmHg pressure, respectively. There were no significant differences in hemolysis markers (hemoglobin, hematocrit, lactate dehydrogenase, and plasma free hemoglobin) or erythrocyte rheology (deformability, disaggregating shear stress, and aggregation index) between before and after heating (p > 0.05) except LDH at gravity (p = 0.0001). CONCLUSION: The ThermoSens® fluid warmer caused no erythrocyte injury or negative effects on rheology during heating. Regarding medical device development, hemorheologic analysis can be useful for safety evaluation of medical devices that directly contact blood for temperature modulation.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalClinical Hemorheology and Microcirculation
Volume62
Issue number1
DOIs
Publication statusPublished - 2016 Feb 16

Fingerprint

Heating
Rheology
Hemolysis
Erythrocytes
Safety
Gravitation
Hemoglobins
Equipment Safety
Erythrocyte Deformability
Blood Safety
Pressure
Blood Banks
Temperature
Wounds and Injuries
Hematocrit
L-Lactate Dehydrogenase
Equipment and Supplies

Keywords

  • Fluid warmer
  • heating
  • hemolysis
  • hemorheology
  • hypothermia
  • transfusion

ASJC Scopus subject areas

  • Physiology
  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Evaluation of fluid warmer safety using hemorheologic analysis with outdated human blood. / Kim, Hee Jung; Yoo, Sung Mook; Chung, Jae Ho; Kim, Tae Sik; Lee, Sung Ho; Son, Ho Sung.

In: Clinical Hemorheology and Microcirculation, Vol. 62, No. 1, 16.02.2016, p. 13-17.

Research output: Contribution to journalArticle

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