Évaluation de l'ELISA de Plasmodium vivax pour le dépistage sanguin

Translated title of the contribution: Evaluation of Plasmodium vivax ELISA for the blood screen

Myung-Hyun Nam, Jang Su Kim, Chy Hyun Cho, Eun Taek Han, Won Ja Lee, Hee Kyung Lee, Seong Soo A An, Chae Seung Lim, Kap No Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Summary: Plasmodium vivax malaria is the indigenous strain in the Republic of Korea (ROK). Plasmodium vivax can be transmitted through the transfusions of various blood components, which became a severe problem with the safety of blood transfusions and blood-related products in ROK. We evaluated a P. vivax-specific enzyme-linked immunosorbent assay (Genedia Malaria Ab ELISA 2.0, Green Cross, ROK) with blood samples from four groups: 251 samples from P. vivax-infected patients, 39 samples from post-treatment patients upon follow-up, 200 samples from healthy volunteers and 421 samples from domestic travellers to and from high endemic areas of ROK. The positive cases from the ELISA test were confirmed by both Giemsa microscopic and polymerase chain reaction methods. The clinical sensitivity and specificity of detecting P. vivax with ELISA test were 94.4% and 99.0%, respectively. Thirteen of 421 domestic travellers (3.0%) to endemic areas tested positive. The results indicate the effectiveness of detecting antibodies against P. vivax in blood with Genedia Malaria Ab ELISA 2.0 test in a large blood screen setting.

Original languageFrench
Pages (from-to)1436-1441
Number of pages6
JournalTropical Medicine and International Health
Volume15
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

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Keywords

  • Antibody test
  • ELISA
  • Plasmodium vivax
  • Republic of Korea

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Parasitology

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