Evaluation of the association between gestational diabetes mellitus at first pregnancy and cancer within 10 years postpartum using national health insurance data in South Korea

Kyu Tae Han, Geum-Joon Cho, Eui Hyeok Kim

Research output: Contribution to journalArticle

Abstract

This study aims to evaluate the association between gestational diabetes mellitus (GDM) at first pregnancy and the incidence of cancer within 10 years postpartum. We used customized health information data from the National Health Insurance Corporation (NHIC). This retrospective cohort study included data from women who were not previously diagnosed with diabetes or any kind of malignancy in the National Health Screening Examination through the NHIC during 2002–2003, and only women who had their first delivery between 2004 and 2005 was included. Follow-up cancer diagnosis was carried out up until 2015. Among the 102,900 primiparous women, 4970 (4.83%) were diagnosed with GDM. During 10 year total follow-up period, 6569 (6.38%) cases of primary cancer were identified. The incidence of cancer was higher in women with GDM and the most common type of cancer was thyroid cancer, followed by breast cancer. On the basis of survival analysis, we adopted the Cox proportional hazards model and found that GDM was positively associated with cancer, particularly in thyroid cancer (HR: 1.27, 95% CI: 1.054–1.532, p = 0.012). However, the incidence of other malignancies (including ovarian and breast cancers) were not significantly associated with GDM, though they did show positive trends. Our findings suggest that GDM is associated with the incidence of cancer, particular thyroid cancer.

Original languageEnglish
Article number2646
JournalInternational Journal of Environmental Research and Public Health
Volume15
Issue number12
DOIs
Publication statusPublished - 2018 Dec 1

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Republic of Korea
Gestational Diabetes
National Health Programs
Postpartum Period
Thyroid Neoplasms
Pregnancy
Neoplasms
Incidence
Breast Neoplasms
Health
Survival Analysis
Proportional Hazards Models
Ovarian Neoplasms
Cohort Studies
Retrospective Studies

Keywords

  • Cancer
  • Diabetes mellitus
  • Gestational diabetes mellitus
  • Thyroid cancer

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

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title = "Evaluation of the association between gestational diabetes mellitus at first pregnancy and cancer within 10 years postpartum using national health insurance data in South Korea",
abstract = "This study aims to evaluate the association between gestational diabetes mellitus (GDM) at first pregnancy and the incidence of cancer within 10 years postpartum. We used customized health information data from the National Health Insurance Corporation (NHIC). This retrospective cohort study included data from women who were not previously diagnosed with diabetes or any kind of malignancy in the National Health Screening Examination through the NHIC during 2002–2003, and only women who had their first delivery between 2004 and 2005 was included. Follow-up cancer diagnosis was carried out up until 2015. Among the 102,900 primiparous women, 4970 (4.83{\%}) were diagnosed with GDM. During 10 year total follow-up period, 6569 (6.38{\%}) cases of primary cancer were identified. The incidence of cancer was higher in women with GDM and the most common type of cancer was thyroid cancer, followed by breast cancer. On the basis of survival analysis, we adopted the Cox proportional hazards model and found that GDM was positively associated with cancer, particularly in thyroid cancer (HR: 1.27, 95{\%} CI: 1.054–1.532, p = 0.012). However, the incidence of other malignancies (including ovarian and breast cancers) were not significantly associated with GDM, though they did show positive trends. Our findings suggest that GDM is associated with the incidence of cancer, particular thyroid cancer.",
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