Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle

Pyo June Pak, Eun Byeol Go, Min Hee Hwang, Dong Gun Lee, Mi Ju Cho, Yong Hoon Joo, Namhyun Chung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recently, conjugates of medicinal herb-derived bioflavonoids, such as quercetin, and gold nanoparticles (GNPs) have gained attention as targeted drug delivery systems. In the present study, because quercetin is an important flavonoid with anticancer, anti-inflammatory, and anti-oxidant properties, GNP-quercetin complexes (GNPQs) were synthesized to investigate possible adverse effects such as cytotoxicity. We found that while quercetin was cytotoxic, GNPQs were not cytotoxic towards the RAW 264.7 and THP-1 cell lines. Therefore, GNPQs may serve as a potential drug delivery system for cancer treatment.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalJournal of Applied Biological Chemistry
Volume59
Issue number2
DOIs
Publication statusPublished - 2016 Jun 1

Keywords

  • Citrate synthesis
  • Drug delivery system
  • Gold nanoparticle
  • Quercetin

ASJC Scopus subject areas

  • Organic Chemistry
  • Bioengineering

Fingerprint Dive into the research topics of 'Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle'. Together they form a unique fingerprint.

  • Cite this