Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle

Pyo June Pak, Eun Byeol Go, Min Hee Hwang, Dong Gun Lee, Mi Ju Cho, Yong Hoon Joo, Namhyun Chung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recently, conjugates of medicinal herb-derived bioflavonoids, such as quercetin, and gold nanoparticles (GNPs) have gained attention as targeted drug delivery systems. In the present study, because quercetin is an important flavonoid with anticancer, anti-inflammatory, and anti-oxidant properties, GNP-quercetin complexes (GNPQs) were synthesized to investigate possible adverse effects such as cytotoxicity. We found that while quercetin was cytotoxic, GNPQs were not cytotoxic towards the RAW 264.7 and THP-1 cell lines. Therefore, GNPQs may serve as a potential drug delivery system for cancer treatment.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalJournal of Applied Biological Chemistry
Volume59
Issue number2
DOIs
Publication statusPublished - 2016 Jun 1

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Quercetin
Cytotoxicity
Drug delivery
Gold
Nanoparticles
Flavonoids
Oncology
Oxidants
Cells
Anti-Inflammatory Agents
Drug Delivery Systems
Targeted drug delivery

Keywords

  • Citrate synthesis
  • Drug delivery system
  • Gold nanoparticle
  • Quercetin

ASJC Scopus subject areas

  • Organic Chemistry
  • Bioengineering

Cite this

Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle. / Pak, Pyo June; Go, Eun Byeol; Hwang, Min Hee; Lee, Dong Gun; Cho, Mi Ju; Joo, Yong Hoon; Chung, Namhyun.

In: Journal of Applied Biological Chemistry, Vol. 59, No. 2, 01.06.2016, p. 145-147.

Research output: Contribution to journalArticle

Pak, Pyo June ; Go, Eun Byeol ; Hwang, Min Hee ; Lee, Dong Gun ; Cho, Mi Ju ; Joo, Yong Hoon ; Chung, Namhyun. / Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle. In: Journal of Applied Biological Chemistry. 2016 ; Vol. 59, No. 2. pp. 145-147.
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