Evaluation of the inhibition of mushroom tyrosinase and cellular tyrosinase activities of oxyresveratrol: Comparison with mulberroside A

Jeong Keun Kim, Keun Tae Park, Hyun Sun Lee, Mijin Kim, Young Hee Lim

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The inhibitory effects of oxyresveratrol, the aglycone of mulberroside A, on mushroom and cellular tyrosinase activities and melanin synthesis were evaluated. Mulberroside A and oxyresveratrol showed inhibitory activity against mushroom tyrosinase, with oxyresveratrol demonstrating a greater inhibitory effect than that of mulberroside A. Oxyresveratrol and mulberroside A strongly inhibited melanin production in Streptomyces bikiniensis and exhibited dose-dependent inhibition of tyrosinase activity and inhibition of melanin synthesis in B16F10 melanoma cells. However, the compounds exhibited nearly similar inhibitory effects on the activity of cellular tyrosinase and melanin synthesis in murine melanocytes. The inhibition of melanin synthesis by mulberroside A and oxyresveratrol was involved in suppressing the expression level of melanogenic enzymes, tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2). These results indicate that the inhibition rate of mushroom tyrosinase might not provide an accurate estimate of the inhibition rate of melanin synthesis in melanocytes.

Original languageEnglish
Pages (from-to)495-503
Number of pages9
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Issue number4
Publication statusPublished - 2012 Aug 1



  • Melanin synthesis inhibition
  • Mulberroside A
  • Oxyresveratrol
  • Tyrosinase activity inhibition

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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