Evaluation of the prognostic powers of various tumor status grading scales in patients with hepatocellular carcinoma

Yeon Seok Seo, Young Jin Kim, Soon Ho Um, Hanna Yoo, Jae Won Lee, Yong Sik Kim, Yoon Tae Jeen, Hoon Jai Chun, Chang Duck Kim, Ho Sang Ryu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Backgrounds and Aim: Several tumor status grading scales are available for patients with hepatocellular carcinoma (HCC), which include several tumor-node-metastasis (TNM) systems and clinical staging systems, such as Cancer of the Liver Italian Program (CLIP) and Barcelona Clinic Liver Cancer (BCLC). This study was performed to analyze the prognostic powers of these tumor status grading systems in HCC. Methods: A retrospective cohort of 499 consecutive patients with HCC was included. The tumor statuses of all patients were classified according to several TNM systems (sixth version of the American Joint Committee on Cancer, fourth version of the Liver Cancer Study Group of Japan [LCSGJ], and the United Network for Organ Sharing UNOS system) and according to the tumor status grading scales of the BCLC (TBCLC) and CLIP (TCLIP) systems. Prognostic powers were quantified using a linear trend χ2-test, c-index, and the likelihood ratio (LHR) χ2-test, and correlated using Cox's regression model adjusted using the Akaike information criterion (AIC). Results: Of the TNM systems, the fourth LCSGJ system had the highest prognostic power (LHR χ2 = 7.20, AIC = 4803.02). However, when TBCLC and TCLIP were included in the analysis, TCLIP showed the best predictive power (LHR χ2 = 29.52, AIC = 4799.82). Conclusion: TCLIP had best predictive power in HCC patients of the various tumor staging systems examined. To improve prognostic power, factors other than tumor burden, such as tumor behavior, should be included in the tumor status grading system for HCC.

Original languageEnglish
Pages (from-to)1267-1275
Number of pages9
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume23
Issue number8 PART1
DOIs
Publication statusPublished - 2008 Aug

Keywords

  • Hepatocellular carcinoma
  • Prognostic power
  • Staging system

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Evaluation of the prognostic powers of various tumor status grading scales in patients with hepatocellular carcinoma'. Together they form a unique fingerprint.

  • Cite this

    Seo, Y. S., Kim, Y. J., Um, S. H., Yoo, H., Lee, J. W., Kim, Y. S., Jeen, Y. T., Chun, H. J., Kim, C. D., & Ryu, H. S. (2008). Evaluation of the prognostic powers of various tumor status grading scales in patients with hepatocellular carcinoma. Journal of Gastroenterology and Hepatology (Australia), 23(8 PART1), 1267-1275. https://doi.org/10.1111/j.1440-1746.2008.05480.x