Evaluation on skin irritation and sensitization of oxyresveratrol and oxyresveratrol-3-O-glucoside produced by biotransformation of Morus alba extract

Keun Tae Park, Jeong Keun Kim, Young Hee Lim

Research output: Contribution to journalArticle

Abstract

Stilbenes are known as antioxidants and some of them demonstrate anti-pigmentation activity. The purpose of the present study was to investigate whether two stilbene compounds produced by biotransformation of the extract of Morus alba root show skin irritation and sensitization. In skin irritation test, 1% oxyresveratrol (OXY), and 5% OXY, and 1% oxyresveratrol-3-O-glucoside (OXY-3) showed a P.I.I score of 0, 0.04, and 0, respectively. Accordingly, the two stilbenes were evaluated to be virtually 'non-irritant' materials. In a skin sensitization study by GPMT, 1% OXY, 5% OXY, and 1% OXY-3 did not cause edema and erythema at 24 h and 48 h after topical application and exhibited a sensitization score of 0 and a rate of 0%. Consequently, it was confirmed that OXY and OXY-3 had no contact allergic sensitization in GPMT. Therefore, OXY and OXY-3 might be potential candidates as skin-whitening agents without posing any serious side effects.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalKorean Journal of Food Science and Technology
Volume44
Issue number2
Publication statusPublished - 2012 Apr 1

Fingerprint

skin irritation
Morus
Morus alba
stilbenes
Biotransformation
biotransformation
glucosides
Skin
extracts
Stilbenes
erythema
topical application
pigmentation
edema
adverse effects
antioxidants
Skin Lightening Preparations
puag-haad
oxyresveratrol-3-O-glucoside
testing

Keywords

  • Guinea pig maximization test
  • Morus alba extract
  • Skin irritation
  • Skin sensitization

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

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title = "Evaluation on skin irritation and sensitization of oxyresveratrol and oxyresveratrol-3-O-glucoside produced by biotransformation of Morus alba extract",
abstract = "Stilbenes are known as antioxidants and some of them demonstrate anti-pigmentation activity. The purpose of the present study was to investigate whether two stilbene compounds produced by biotransformation of the extract of Morus alba root show skin irritation and sensitization. In skin irritation test, 1{\%} oxyresveratrol (OXY), and 5{\%} OXY, and 1{\%} oxyresveratrol-3-O-glucoside (OXY-3) showed a P.I.I score of 0, 0.04, and 0, respectively. Accordingly, the two stilbenes were evaluated to be virtually 'non-irritant' materials. In a skin sensitization study by GPMT, 1{\%} OXY, 5{\%} OXY, and 1{\%} OXY-3 did not cause edema and erythema at 24 h and 48 h after topical application and exhibited a sensitization score of 0 and a rate of 0{\%}. Consequently, it was confirmed that OXY and OXY-3 had no contact allergic sensitization in GPMT. Therefore, OXY and OXY-3 might be potential candidates as skin-whitening agents without posing any serious side effects.",
keywords = "Guinea pig maximization test, Morus alba extract, Skin irritation, Skin sensitization",
author = "Park, {Keun Tae} and Kim, {Jeong Keun} and Lim, {Young Hee}",
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AU - Lim, Young Hee

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N2 - Stilbenes are known as antioxidants and some of them demonstrate anti-pigmentation activity. The purpose of the present study was to investigate whether two stilbene compounds produced by biotransformation of the extract of Morus alba root show skin irritation and sensitization. In skin irritation test, 1% oxyresveratrol (OXY), and 5% OXY, and 1% oxyresveratrol-3-O-glucoside (OXY-3) showed a P.I.I score of 0, 0.04, and 0, respectively. Accordingly, the two stilbenes were evaluated to be virtually 'non-irritant' materials. In a skin sensitization study by GPMT, 1% OXY, 5% OXY, and 1% OXY-3 did not cause edema and erythema at 24 h and 48 h after topical application and exhibited a sensitization score of 0 and a rate of 0%. Consequently, it was confirmed that OXY and OXY-3 had no contact allergic sensitization in GPMT. Therefore, OXY and OXY-3 might be potential candidates as skin-whitening agents without posing any serious side effects.

AB - Stilbenes are known as antioxidants and some of them demonstrate anti-pigmentation activity. The purpose of the present study was to investigate whether two stilbene compounds produced by biotransformation of the extract of Morus alba root show skin irritation and sensitization. In skin irritation test, 1% oxyresveratrol (OXY), and 5% OXY, and 1% oxyresveratrol-3-O-glucoside (OXY-3) showed a P.I.I score of 0, 0.04, and 0, respectively. Accordingly, the two stilbenes were evaluated to be virtually 'non-irritant' materials. In a skin sensitization study by GPMT, 1% OXY, 5% OXY, and 1% OXY-3 did not cause edema and erythema at 24 h and 48 h after topical application and exhibited a sensitization score of 0 and a rate of 0%. Consequently, it was confirmed that OXY and OXY-3 had no contact allergic sensitization in GPMT. Therefore, OXY and OXY-3 might be potential candidates as skin-whitening agents without posing any serious side effects.

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