Evaluation on skin irritation of bee venom in human

Eun Hye Han, Mi Kyung Lim, Sang Ho Lee, Keun Tae Park, Ji Eun Park, Young Hee Lim, Insuk Sim

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to investigate the skin irritation of bee venom (melittin) in human. Skin irritation test was performed at 0.05% bee venom by 48 h single patch test in 30 healthy volunteers with no skin disease and skin sensitization test was performed by local lymph node assay in animal. In single patch test, 28 human subjects showed no reaction and 2 subjects showed 1+ or 3+ grade skin reaction. In a skin sensitization test of bee venom conducted using mice. no erythema was observed on the dorsal side of mice up to 8 days after application of bee venom on the skin. The results of the average stimulation index by ATP values showed that there was no irritation to the mice skin at 0.005% and 0.01% of bee venom. Therefore, bee venom is not likely to induce a significant skin irritation under 0.05% concentration.

Original languageEnglish
Pages (from-to)202-207
Number of pages6
JournalKorean Journal of Pharmacognosy
Volume48
Issue number3
Publication statusPublished - 2017

Fingerprint

Bee Venoms
Skin
Skin Tests
Patch Tests
Local Lymph Node Assay
Melitten
Erythema
Skin Diseases
Healthy Volunteers
Adenosine Triphosphate

Keywords

  • Bee venom
  • Local lymph node assay
  • Melittin
  • Skin irritation
  • Skin sensitization

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Han, E. H., Lim, M. K., Lee, S. H., Park, K. T., Park, J. E., Lim, Y. H., & Sim, I. (2017). Evaluation on skin irritation of bee venom in human. Korean Journal of Pharmacognosy, 48(3), 202-207.

Evaluation on skin irritation of bee venom in human. / Han, Eun Hye; Lim, Mi Kyung; Lee, Sang Ho; Park, Keun Tae; Park, Ji Eun; Lim, Young Hee; Sim, Insuk.

In: Korean Journal of Pharmacognosy, Vol. 48, No. 3, 2017, p. 202-207.

Research output: Contribution to journalArticle

Han, EH, Lim, MK, Lee, SH, Park, KT, Park, JE, Lim, YH & Sim, I 2017, 'Evaluation on skin irritation of bee venom in human', Korean Journal of Pharmacognosy, vol. 48, no. 3, pp. 202-207.
Han EH, Lim MK, Lee SH, Park KT, Park JE, Lim YH et al. Evaluation on skin irritation of bee venom in human. Korean Journal of Pharmacognosy. 2017;48(3):202-207.
Han, Eun Hye ; Lim, Mi Kyung ; Lee, Sang Ho ; Park, Keun Tae ; Park, Ji Eun ; Lim, Young Hee ; Sim, Insuk. / Evaluation on skin irritation of bee venom in human. In: Korean Journal of Pharmacognosy. 2017 ; Vol. 48, No. 3. pp. 202-207.
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