Evening chronotype is associated with metabolic disorders and body composition in middle-aged adults

Ji Hee Yu, Chang Ho Yun, Jae Hee Ahn, Sooyeon Suh, Hyun Joo Cho, Seung Ku Lee, Hye-Jin Yoo, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei-Hyun Baik, Dong Seop Choi, Chol Shin, Nan Hee Kim

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Abstract

Context: Chronotype is a trait determining individual circadian preference in behavioral and biological rhythm relative to external light-dark cycle. However, little is known about the relationship between chronotype and metabolic disorders. Objective: The aim of this study was to examine whether late chronotype is related to metabolic abnormalities and body composition in middle-aged adults, independent of sleep duration and lifestyle. Design and Participants: A total of 1620 participants aged 47-59 years were recruited from the Korean Genome and Epidemiology Study. Main Outcome Measures: Chronotype was assessed by the Morningness-Eveningness Questionnaire. Associations of chronotype with diabetes, metabolic syndrome, sarcopenia, and visceral obesity were analyzed. All participants underwent the oral glucose tolerance test, and body composition was measured with dual energy x-ray absorptiometry. Visceral obesity was designated as visceral fat area, measured by abdominal computed tomography, of >100 cm<sup>2</sup>. Results: Chronotype was classified as morning in 29.6% of subjects, evening in 5.9%, neither morning nor evening in 64.5%. Evening type, whencompared with morning type, was significantly associated with diabetes (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.01-2.95), metabolic syndrome (OR, 1.74; 95% CI, 1.05-2.87), and sarcopenia (OR, 3.16; 95% CI, 1.36-7.33) after adjusting for confounding factors. Gender differences in the associations were evident. In men, evening type was associated with diabetes (OR, 2.98; 95% CI, 1.39-6.39) and sarcopenia (OR, 3.89; 95% CI, 1.33-11.33). Only metabolic syndrome was associated with evening type in women (OR, 2.22; 95% CI, 1.11-4.43). Conclusions: At the population level, evening chronotype was independently associated with diabetes, metabolic syndrome, and sarcopenia. These results support the importance of circadian rhythms in metabolic regulation.

Original languageEnglish
Pages (from-to)1494-1502
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number4
DOIs
Publication statusPublished - 2015 Apr 1

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Medical problems
Body Composition
Sarcopenia
Odds Ratio
Confidence Intervals
Chemical analysis
Abdominal Obesity
Epidemiology
Tomography
Intra-Abdominal Fat
Genes
Fats
Photoperiod
Periodicity
Glucose Tolerance Test
Circadian Rhythm
Glucose
X rays
Life Style
Sleep

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Evening chronotype is associated with metabolic disorders and body composition in middle-aged adults. / Yu, Ji Hee; Yun, Chang Ho; Ahn, Jae Hee; Suh, Sooyeon; Cho, Hyun Joo; Lee, Seung Ku; Yoo, Hye-Jin; Seo, Ji A; Kim, Sin Gon; Choi, Kyung Mook; Baik, Sei-Hyun; Choi, Dong Seop; Shin, Chol; Kim, Nan Hee.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 4, 01.04.2015, p. 1494-1502.

Research output: Contribution to journalArticle

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abstract = "Context: Chronotype is a trait determining individual circadian preference in behavioral and biological rhythm relative to external light-dark cycle. However, little is known about the relationship between chronotype and metabolic disorders. Objective: The aim of this study was to examine whether late chronotype is related to metabolic abnormalities and body composition in middle-aged adults, independent of sleep duration and lifestyle. Design and Participants: A total of 1620 participants aged 47-59 years were recruited from the Korean Genome and Epidemiology Study. Main Outcome Measures: Chronotype was assessed by the Morningness-Eveningness Questionnaire. Associations of chronotype with diabetes, metabolic syndrome, sarcopenia, and visceral obesity were analyzed. All participants underwent the oral glucose tolerance test, and body composition was measured with dual energy x-ray absorptiometry. Visceral obesity was designated as visceral fat area, measured by abdominal computed tomography, of >100 cm2. Results: Chronotype was classified as morning in 29.6{\%} of subjects, evening in 5.9{\%}, neither morning nor evening in 64.5{\%}. Evening type, whencompared with morning type, was significantly associated with diabetes (odds ratio [OR], 1.73; 95{\%} confidence interval [CI], 1.01-2.95), metabolic syndrome (OR, 1.74; 95{\%} CI, 1.05-2.87), and sarcopenia (OR, 3.16; 95{\%} CI, 1.36-7.33) after adjusting for confounding factors. Gender differences in the associations were evident. In men, evening type was associated with diabetes (OR, 2.98; 95{\%} CI, 1.39-6.39) and sarcopenia (OR, 3.89; 95{\%} CI, 1.33-11.33). Only metabolic syndrome was associated with evening type in women (OR, 2.22; 95{\%} CI, 1.11-4.43). Conclusions: At the population level, evening chronotype was independently associated with diabetes, metabolic syndrome, and sarcopenia. These results support the importance of circadian rhythms in metabolic regulation.",
author = "Yu, {Ji Hee} and Yun, {Chang Ho} and Ahn, {Jae Hee} and Sooyeon Suh and Cho, {Hyun Joo} and Lee, {Seung Ku} and Hye-Jin Yoo and Seo, {Ji A} and Kim, {Sin Gon} and Choi, {Kyung Mook} and Sei-Hyun Baik and Choi, {Dong Seop} and Chol Shin and Kim, {Nan Hee}",
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T1 - Evening chronotype is associated with metabolic disorders and body composition in middle-aged adults

AU - Yu, Ji Hee

AU - Yun, Chang Ho

AU - Ahn, Jae Hee

AU - Suh, Sooyeon

AU - Cho, Hyun Joo

AU - Lee, Seung Ku

AU - Yoo, Hye-Jin

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Choi, Kyung Mook

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Shin, Chol

AU - Kim, Nan Hee

PY - 2015/4/1

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N2 - Context: Chronotype is a trait determining individual circadian preference in behavioral and biological rhythm relative to external light-dark cycle. However, little is known about the relationship between chronotype and metabolic disorders. Objective: The aim of this study was to examine whether late chronotype is related to metabolic abnormalities and body composition in middle-aged adults, independent of sleep duration and lifestyle. Design and Participants: A total of 1620 participants aged 47-59 years were recruited from the Korean Genome and Epidemiology Study. Main Outcome Measures: Chronotype was assessed by the Morningness-Eveningness Questionnaire. Associations of chronotype with diabetes, metabolic syndrome, sarcopenia, and visceral obesity were analyzed. All participants underwent the oral glucose tolerance test, and body composition was measured with dual energy x-ray absorptiometry. Visceral obesity was designated as visceral fat area, measured by abdominal computed tomography, of >100 cm2. Results: Chronotype was classified as morning in 29.6% of subjects, evening in 5.9%, neither morning nor evening in 64.5%. Evening type, whencompared with morning type, was significantly associated with diabetes (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.01-2.95), metabolic syndrome (OR, 1.74; 95% CI, 1.05-2.87), and sarcopenia (OR, 3.16; 95% CI, 1.36-7.33) after adjusting for confounding factors. Gender differences in the associations were evident. In men, evening type was associated with diabetes (OR, 2.98; 95% CI, 1.39-6.39) and sarcopenia (OR, 3.89; 95% CI, 1.33-11.33). Only metabolic syndrome was associated with evening type in women (OR, 2.22; 95% CI, 1.11-4.43). Conclusions: At the population level, evening chronotype was independently associated with diabetes, metabolic syndrome, and sarcopenia. These results support the importance of circadian rhythms in metabolic regulation.

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