Abstract
Context: Chronotype is a trait determining individual circadian preference in behavioral and biological rhythm relative to external light-dark cycle. However, little is known about the relationship between chronotype and metabolic disorders. Objective: The aim of this study was to examine whether late chronotype is related to metabolic abnormalities and body composition in middle-aged adults, independent of sleep duration and lifestyle. Design and Participants: A total of 1620 participants aged 47-59 years were recruited from the Korean Genome and Epidemiology Study. Main Outcome Measures: Chronotype was assessed by the Morningness-Eveningness Questionnaire. Associations of chronotype with diabetes, metabolic syndrome, sarcopenia, and visceral obesity were analyzed. All participants underwent the oral glucose tolerance test, and body composition was measured with dual energy x-ray absorptiometry. Visceral obesity was designated as visceral fat area, measured by abdominal computed tomography, of >100 cm<sup>2</sup>. Results: Chronotype was classified as morning in 29.6% of subjects, evening in 5.9%, neither morning nor evening in 64.5%. Evening type, whencompared with morning type, was significantly associated with diabetes (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.01-2.95), metabolic syndrome (OR, 1.74; 95% CI, 1.05-2.87), and sarcopenia (OR, 3.16; 95% CI, 1.36-7.33) after adjusting for confounding factors. Gender differences in the associations were evident. In men, evening type was associated with diabetes (OR, 2.98; 95% CI, 1.39-6.39) and sarcopenia (OR, 3.89; 95% CI, 1.33-11.33). Only metabolic syndrome was associated with evening type in women (OR, 2.22; 95% CI, 1.11-4.43). Conclusions: At the population level, evening chronotype was independently associated with diabetes, metabolic syndrome, and sarcopenia. These results support the importance of circadian rhythms in metabolic regulation.
| Original language | English |
|---|---|
| Pages (from-to) | 1494-1502 |
| Number of pages | 9 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 100 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2015 Apr 1 |
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ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Endocrinology
- Biochemistry, medical
- Endocrinology, Diabetes and Metabolism
Cite this
Evening chronotype is associated with metabolic disorders and body composition in middle-aged adults. / Yu, Ji Hee; Yun, Chang Ho; Ahn, Jae Hee; Suh, Sooyeon; Cho, Hyun Joo; Lee, Seung Ku; Yoo, Hye-Jin; Seo, Ji A; Kim, Sin Gon; Choi, Kyung Mook; Baik, Sei-Hyun; Choi, Dong Seop; Shin, Chol; Kim, Nan Hee.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 4, 01.04.2015, p. 1494-1502.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evening chronotype is associated with metabolic disorders and body composition in middle-aged adults
AU - Yu, Ji Hee
AU - Yun, Chang Ho
AU - Ahn, Jae Hee
AU - Suh, Sooyeon
AU - Cho, Hyun Joo
AU - Lee, Seung Ku
AU - Yoo, Hye-Jin
AU - Seo, Ji A
AU - Kim, Sin Gon
AU - Choi, Kyung Mook
AU - Baik, Sei-Hyun
AU - Choi, Dong Seop
AU - Shin, Chol
AU - Kim, Nan Hee
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Context: Chronotype is a trait determining individual circadian preference in behavioral and biological rhythm relative to external light-dark cycle. However, little is known about the relationship between chronotype and metabolic disorders. Objective: The aim of this study was to examine whether late chronotype is related to metabolic abnormalities and body composition in middle-aged adults, independent of sleep duration and lifestyle. Design and Participants: A total of 1620 participants aged 47-59 years were recruited from the Korean Genome and Epidemiology Study. Main Outcome Measures: Chronotype was assessed by the Morningness-Eveningness Questionnaire. Associations of chronotype with diabetes, metabolic syndrome, sarcopenia, and visceral obesity were analyzed. All participants underwent the oral glucose tolerance test, and body composition was measured with dual energy x-ray absorptiometry. Visceral obesity was designated as visceral fat area, measured by abdominal computed tomography, of >100 cm2. Results: Chronotype was classified as morning in 29.6% of subjects, evening in 5.9%, neither morning nor evening in 64.5%. Evening type, whencompared with morning type, was significantly associated with diabetes (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.01-2.95), metabolic syndrome (OR, 1.74; 95% CI, 1.05-2.87), and sarcopenia (OR, 3.16; 95% CI, 1.36-7.33) after adjusting for confounding factors. Gender differences in the associations were evident. In men, evening type was associated with diabetes (OR, 2.98; 95% CI, 1.39-6.39) and sarcopenia (OR, 3.89; 95% CI, 1.33-11.33). Only metabolic syndrome was associated with evening type in women (OR, 2.22; 95% CI, 1.11-4.43). Conclusions: At the population level, evening chronotype was independently associated with diabetes, metabolic syndrome, and sarcopenia. These results support the importance of circadian rhythms in metabolic regulation.
AB - Context: Chronotype is a trait determining individual circadian preference in behavioral and biological rhythm relative to external light-dark cycle. However, little is known about the relationship between chronotype and metabolic disorders. Objective: The aim of this study was to examine whether late chronotype is related to metabolic abnormalities and body composition in middle-aged adults, independent of sleep duration and lifestyle. Design and Participants: A total of 1620 participants aged 47-59 years were recruited from the Korean Genome and Epidemiology Study. Main Outcome Measures: Chronotype was assessed by the Morningness-Eveningness Questionnaire. Associations of chronotype with diabetes, metabolic syndrome, sarcopenia, and visceral obesity were analyzed. All participants underwent the oral glucose tolerance test, and body composition was measured with dual energy x-ray absorptiometry. Visceral obesity was designated as visceral fat area, measured by abdominal computed tomography, of >100 cm2. Results: Chronotype was classified as morning in 29.6% of subjects, evening in 5.9%, neither morning nor evening in 64.5%. Evening type, whencompared with morning type, was significantly associated with diabetes (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.01-2.95), metabolic syndrome (OR, 1.74; 95% CI, 1.05-2.87), and sarcopenia (OR, 3.16; 95% CI, 1.36-7.33) after adjusting for confounding factors. Gender differences in the associations were evident. In men, evening type was associated with diabetes (OR, 2.98; 95% CI, 1.39-6.39) and sarcopenia (OR, 3.89; 95% CI, 1.33-11.33). Only metabolic syndrome was associated with evening type in women (OR, 2.22; 95% CI, 1.11-4.43). Conclusions: At the population level, evening chronotype was independently associated with diabetes, metabolic syndrome, and sarcopenia. These results support the importance of circadian rhythms in metabolic regulation.
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UR - http://www.scopus.com/inward/citedby.url?scp=84927660095&partnerID=8YFLogxK
U2 - 10.1210/jc.2014-3754
DO - 10.1210/jc.2014-3754
M3 - Article
C2 - 25831477
AN - SCOPUS:84927660095
VL - 100
SP - 1494
EP - 1502
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 4
ER -