Abstract
Hippocampus is one of the earliest brain regions that gets affected by ischemia, however, no pharmacological therapy exists yet that can fully counteract the ischemic damage. Here we study the effect of sulbutiamine, a synthetic thiamine analogue that can cross the blood-brain barrier easily, on hippocampal neurons under an in vitro model of ischemia, oxygen-glucose deprivation (OGD). We find that exposure to OGD in the presence of sulbutiamine significantly increases neuronal viability and enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Overall, here we report, for the first time, the neuroprotective evidence of sulbutiamine on hippocampal CA1 pyramidal neurons under OGD, which may have beneficial implications as a possible therapeutic agent/substance against ischemic insult.
| Original language | English |
|---|---|
| Pages (from-to) | 1759-1764 |
| Number of pages | 6 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 34 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2011 Nov 1 |
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Keywords
- Hippocampus
- Neuroprotec
- Oxygen-glucose deprivation
- Sulbutiamine
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology
Cite this
Evidence for neuroprotective effect of sulbutiamine against oxygen-glucose deprivation in rat hippocampal CA1 pyramidal neurons. / Kwag, Jeehyun; Majid, Aman Shah Abdul; Kang, Kui Dong.
In: Biological and Pharmaceutical Bulletin, Vol. 34, No. 11, 01.11.2011, p. 1759-1764.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evidence for neuroprotective effect of sulbutiamine against oxygen-glucose deprivation in rat hippocampal CA1 pyramidal neurons
AU - Kwag, Jeehyun
AU - Majid, Aman Shah Abdul
AU - Kang, Kui Dong
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Hippocampus is one of the earliest brain regions that gets affected by ischemia, however, no pharmacological therapy exists yet that can fully counteract the ischemic damage. Here we study the effect of sulbutiamine, a synthetic thiamine analogue that can cross the blood-brain barrier easily, on hippocampal neurons under an in vitro model of ischemia, oxygen-glucose deprivation (OGD). We find that exposure to OGD in the presence of sulbutiamine significantly increases neuronal viability and enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Overall, here we report, for the first time, the neuroprotective evidence of sulbutiamine on hippocampal CA1 pyramidal neurons under OGD, which may have beneficial implications as a possible therapeutic agent/substance against ischemic insult.
AB - Hippocampus is one of the earliest brain regions that gets affected by ischemia, however, no pharmacological therapy exists yet that can fully counteract the ischemic damage. Here we study the effect of sulbutiamine, a synthetic thiamine analogue that can cross the blood-brain barrier easily, on hippocampal neurons under an in vitro model of ischemia, oxygen-glucose deprivation (OGD). We find that exposure to OGD in the presence of sulbutiamine significantly increases neuronal viability and enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Overall, here we report, for the first time, the neuroprotective evidence of sulbutiamine on hippocampal CA1 pyramidal neurons under OGD, which may have beneficial implications as a possible therapeutic agent/substance against ischemic insult.
KW - Hippocampus
KW - Neuroprotec
KW - Oxygen-glucose deprivation
KW - Sulbutiamine
UR - http://www.scopus.com/inward/record.url?scp=81455128689&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81455128689&partnerID=8YFLogxK
U2 - 10.1248/bpb.34.1759
DO - 10.1248/bpb.34.1759
M3 - Article
C2 - 22040892
AN - SCOPUS:81455128689
VL - 34
SP - 1759
EP - 1764
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 11
ER -