Abstract
Understanding of how protein interaction networks (PIN) of living organisms have evolved or are organized can be the first stepping stone in unveiling how life works on a fundamental basis. Here, we introduce a new in-silico evolution model of the PIN of budding yeast, Saccharomyces cerevisiae; the model is composed of the PIN and the protein family network. The basic ingredient of the model includes family compatibility which constrains the potential binding ability of a protein, as well as the previously proposed gene duplication, divergence, and mutation. We investigate various structural properties of our model network with parameter values relevant to budding yeast and find that the model successfully reproduces the empirical data.
| Original language | English |
|---|---|
| Pages (from-to) | 551-555 |
| Number of pages | 5 |
| Journal | Journal of the Korean Physical Society |
| Volume | 46 |
| Issue number | 2 |
| Publication status | Published - 2005 Feb 1 |
| Externally published | Yes |
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Keywords
- Family compatibility
- Protein interaction network
ASJC Scopus subject areas
- Physics and Astronomy(all)
Cite this
Evolution of the protein interaction network of budding yeast : Role of the protein family compatibility constraint. / Goh, Kwang-Il; Kahng, B.; Kim, D.
In: Journal of the Korean Physical Society, Vol. 46, No. 2, 01.02.2005, p. 551-555.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evolution of the protein interaction network of budding yeast
T2 - Role of the protein family compatibility constraint
AU - Goh, Kwang-Il
AU - Kahng, B.
AU - Kim, D.
PY - 2005/2/1
Y1 - 2005/2/1
N2 - Understanding of how protein interaction networks (PIN) of living organisms have evolved or are organized can be the first stepping stone in unveiling how life works on a fundamental basis. Here, we introduce a new in-silico evolution model of the PIN of budding yeast, Saccharomyces cerevisiae; the model is composed of the PIN and the protein family network. The basic ingredient of the model includes family compatibility which constrains the potential binding ability of a protein, as well as the previously proposed gene duplication, divergence, and mutation. We investigate various structural properties of our model network with parameter values relevant to budding yeast and find that the model successfully reproduces the empirical data.
AB - Understanding of how protein interaction networks (PIN) of living organisms have evolved or are organized can be the first stepping stone in unveiling how life works on a fundamental basis. Here, we introduce a new in-silico evolution model of the PIN of budding yeast, Saccharomyces cerevisiae; the model is composed of the PIN and the protein family network. The basic ingredient of the model includes family compatibility which constrains the potential binding ability of a protein, as well as the previously proposed gene duplication, divergence, and mutation. We investigate various structural properties of our model network with parameter values relevant to budding yeast and find that the model successfully reproduces the empirical data.
KW - Family compatibility
KW - Protein interaction network
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UR - http://www.scopus.com/inward/citedby.url?scp=14744280586&partnerID=8YFLogxK
M3 - Article
VL - 46
SP - 551
EP - 555
JO - Journal of the Korean Physical Society
JF - Journal of the Korean Physical Society
SN - 0374-4884
IS - 2
ER -