Evolution of VX2 carcinoma in rabbit tibia

magnetic resonance imaging with pathologic correlation

Jung Ah Choi, Eun-Young Kang, Han Kyeom Kim, In Chan Song, Young I.I. Kim, Heung Sik Kang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To evaluate the evolution of a metastatic bone tumor model with MRI-pathology correlation. Materials and Methods: VX2 carcinoma was implanted into the tibiae of 20 rabbits. The rabbits were divided into four groups of five (Groups I-IV). MRI was repeated at 1-week interval up to the fourth week, including sagittal T1-weighted image (T1WI), T2-weighted image (T2WI), gadolinium-enhanced fat-suppressed T1WI (GdT1WI), and diffusion-weighted image (DWI). Each group was sacrificed after the imaging, then histological examination for the tibiae with an implanted tumor was performed and MRI-pathologic correlation was done. Results: On MRI-pathology correlation, the corresponding findings were as follows; low SI on T1WI, T2WI-tumor cells, fibrosis (1 week); central low SI on T1WI, T2WI, GdT1WI -tumor cells with fibrosis and necrosis; peripheral high SI on T2WI, DWI, GdT1WI-edema, fibrosis (2 weeks); heterogeneous SI with central low SI on T2WI, DWI-tumor cell nests with extensive necrosis, fibrosis; high SI on T2WI along periosteum-periosteal reaction; high SI around low SI and in bone marrow on T2WI, DWI, GdT1WI-edema, fibrosis; low SI on T1WI in surrounding bone marrow-tumor extension (3-4 weeks). Conclusion: The evolution of VX2 carcinoma model was well depicted on MR imaging. Necrosis and extent of tumor were best depicted on enhanced, fat-suppressed T1-weighted images. Heterogeneity of the tumor, peripheral edema, and fibrosis were represented well on T2-weighted images. Diffusion-weighted imaging could have a role in depicting necrosis in the evaluation of bone tumor.

Original languageEnglish
Pages (from-to)128-135
Number of pages8
JournalClinical Imaging
Volume32
Issue number2
DOIs
Publication statusPublished - 2008 Mar 1

Fingerprint

Tibia
Magnetic Resonance Imaging
Rabbits
Carcinoma
Fibrosis
Gadolinium
Neoplasms
Fats
Necrosis
Edema
Bone Marrow
Pathology
Bone and Bones
Periosteum

Keywords

  • Bone neoplasms
  • contrast enhancement
  • diagnosis
  • experimental
  • Magnetic resonance (MR)
  • MR

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Evolution of VX2 carcinoma in rabbit tibia : magnetic resonance imaging with pathologic correlation. / Choi, Jung Ah; Kang, Eun-Young; Kim, Han Kyeom; Song, In Chan; Kim, Young I.I.; Kang, Heung Sik.

In: Clinical Imaging, Vol. 32, No. 2, 01.03.2008, p. 128-135.

Research output: Contribution to journalArticle

Choi, Jung Ah ; Kang, Eun-Young ; Kim, Han Kyeom ; Song, In Chan ; Kim, Young I.I. ; Kang, Heung Sik. / Evolution of VX2 carcinoma in rabbit tibia : magnetic resonance imaging with pathologic correlation. In: Clinical Imaging. 2008 ; Vol. 32, No. 2. pp. 128-135.
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abstract = "Objective: To evaluate the evolution of a metastatic bone tumor model with MRI-pathology correlation. Materials and Methods: VX2 carcinoma was implanted into the tibiae of 20 rabbits. The rabbits were divided into four groups of five (Groups I-IV). MRI was repeated at 1-week interval up to the fourth week, including sagittal T1-weighted image (T1WI), T2-weighted image (T2WI), gadolinium-enhanced fat-suppressed T1WI (GdT1WI), and diffusion-weighted image (DWI). Each group was sacrificed after the imaging, then histological examination for the tibiae with an implanted tumor was performed and MRI-pathologic correlation was done. Results: On MRI-pathology correlation, the corresponding findings were as follows; low SI on T1WI, T2WI-tumor cells, fibrosis (1 week); central low SI on T1WI, T2WI, GdT1WI -tumor cells with fibrosis and necrosis; peripheral high SI on T2WI, DWI, GdT1WI-edema, fibrosis (2 weeks); heterogeneous SI with central low SI on T2WI, DWI-tumor cell nests with extensive necrosis, fibrosis; high SI on T2WI along periosteum-periosteal reaction; high SI around low SI and in bone marrow on T2WI, DWI, GdT1WI-edema, fibrosis; low SI on T1WI in surrounding bone marrow-tumor extension (3-4 weeks). Conclusion: The evolution of VX2 carcinoma model was well depicted on MR imaging. Necrosis and extent of tumor were best depicted on enhanced, fat-suppressed T1-weighted images. Heterogeneity of the tumor, peripheral edema, and fibrosis were represented well on T2-weighted images. Diffusion-weighted imaging could have a role in depicting necrosis in the evaluation of bone tumor.",
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AB - Objective: To evaluate the evolution of a metastatic bone tumor model with MRI-pathology correlation. Materials and Methods: VX2 carcinoma was implanted into the tibiae of 20 rabbits. The rabbits were divided into four groups of five (Groups I-IV). MRI was repeated at 1-week interval up to the fourth week, including sagittal T1-weighted image (T1WI), T2-weighted image (T2WI), gadolinium-enhanced fat-suppressed T1WI (GdT1WI), and diffusion-weighted image (DWI). Each group was sacrificed after the imaging, then histological examination for the tibiae with an implanted tumor was performed and MRI-pathologic correlation was done. Results: On MRI-pathology correlation, the corresponding findings were as follows; low SI on T1WI, T2WI-tumor cells, fibrosis (1 week); central low SI on T1WI, T2WI, GdT1WI -tumor cells with fibrosis and necrosis; peripheral high SI on T2WI, DWI, GdT1WI-edema, fibrosis (2 weeks); heterogeneous SI with central low SI on T2WI, DWI-tumor cell nests with extensive necrosis, fibrosis; high SI on T2WI along periosteum-periosteal reaction; high SI around low SI and in bone marrow on T2WI, DWI, GdT1WI-edema, fibrosis; low SI on T1WI in surrounding bone marrow-tumor extension (3-4 weeks). Conclusion: The evolution of VX2 carcinoma model was well depicted on MR imaging. Necrosis and extent of tumor were best depicted on enhanced, fat-suppressed T1-weighted images. Heterogeneity of the tumor, peripheral edema, and fibrosis were represented well on T2-weighted images. Diffusion-weighted imaging could have a role in depicting necrosis in the evaluation of bone tumor.

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