TY - JOUR
T1 - Evolutionary and comparative genomics to drive rational drug design, with particular focus on neuropeptide seven-transmembrane receptors
AU - Furlong, Michael
AU - Seong, Jae Young
N1 - Funding Information:
This work was supported by grants from the Research Programs (NRF-2015M3A9E7029172 and 2013R1A2A2A01068295) of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning.
Publisher Copyright:
© 2017 The Korean Society of Applied Pharmacology.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/1
Y1 - 2017/1
N2 - Seven transmembrane receptors (7TMRs), also known as G protein-coupled receptors, are popular targets of drug development, particularly 7TMR systems that are activated by peptide ligands. Although many pharmaceutical drugs have been discovered via conventional bulk analysis techniques the increasing availability of structural and evolutionary data are facilitating change to rational, targeted drug design. This article discusses the appeal of neuropeptide-7TMR systems as drug targets and provides an overview of concepts in the evolution of vertebrate genomes and gene families. Subsequently, methods that use evolutionary concepts and comparative analysis techniques to aid in gene discovery, gene function identification, and novel drug design are provided along with case study examples.
AB - Seven transmembrane receptors (7TMRs), also known as G protein-coupled receptors, are popular targets of drug development, particularly 7TMR systems that are activated by peptide ligands. Although many pharmaceutical drugs have been discovered via conventional bulk analysis techniques the increasing availability of structural and evolutionary data are facilitating change to rational, targeted drug design. This article discusses the appeal of neuropeptide-7TMR systems as drug targets and provides an overview of concepts in the evolution of vertebrate genomes and gene families. Subsequently, methods that use evolutionary concepts and comparative analysis techniques to aid in gene discovery, gene function identification, and novel drug design are provided along with case study examples.
KW - 7TMR
KW - Coevolution
KW - Evolutionary history
KW - G protein-coupled receptor
KW - Gene duplication
KW - Neuropeptide
KW - Whole genome duplication
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U2 - 10.4062/biomolther.2016.199
DO - 10.4062/biomolther.2016.199
M3 - Article
AN - SCOPUS:85008392764
VL - 25
SP - 57
EP - 68
JO - Biomolecules and Therapeutics
JF - Biomolecules and Therapeutics
SN - 1976-9148
IS - 1
ER -