Evolutionary relationship analysis of Middle East respiratory syndrome coronavirus 4a and 4b protein coding sequences

Jin Il Kim, Sehee Park, Joon Yong Bae, Man-Seong Park

Research output: Contribution to journalArticle

Abstract

The 4a and 4b proteins of the Middle East respiratory syndrome coronavirus (MERS-CoV) have been described for their antagonism on host innate immunity. However, unlike clustering patterns of the complete gene sequences of human and camel MERS-CoVs, the 4a and 4b protein coding regions did not constitute species-specific phylogenetic groups. Moreover, given the estimated evolutionary rates of the complete, 4a, and 4b gene sequences, the 4a and 4b proteins might be less affected by species-specific innate immune pressures. These results suggest that the 4a and 4b proteins of MERS-CoV may function against host innate immunity in a manner independent of host species and/or evolutionary clustering patterns.

Original languageEnglish
Article numbere1
JournalJournal of Veterinary Science
Volume20
Issue number2
DOIs
Publication statusPublished - 2019 Mar 1

Fingerprint

Innate Immunity
Cluster Analysis
nucleotide sequences
Camelus
Proteins
proteins
camels
Open Reading Frames
Genes
open reading frames
Pressure
phylogeny
Middle East Respiratory Syndrome Coronavirus
Middle East respiratory syndrome coronavirus
innate immunity

Keywords

  • Middle East respiratory syndrome coronavirus
  • Molecular evolution
  • Phylogeny
  • Zoonoses

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Evolutionary relationship analysis of Middle East respiratory syndrome coronavirus 4a and 4b protein coding sequences. / Kim, Jin Il; Park, Sehee; Bae, Joon Yong; Park, Man-Seong.

In: Journal of Veterinary Science, Vol. 20, No. 2, e1, 01.03.2019.

Research output: Contribution to journalArticle

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