Evolutionary relationship analysis of Middle East respiratory syndrome coronavirus 4a and 4b protein coding sequences

Jin Il Kim, Sehee Park, Joon Yong Bae, Man Seong Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The 4a and 4b proteins of the Middle East respiratory syndrome coronavirus (MERS-CoV) have been described for their antagonism on host innate immunity. However, unlike clustering patterns of the complete gene sequences of human and camel MERS-CoVs, the 4a and 4b protein coding regions did not constitute species-specific phylogenetic groups. Moreover, given the estimated evolutionary rates of the complete, 4a, and 4b gene sequences, the 4a and 4b proteins might be less affected by species-specific innate immune pressures. These results suggest that the 4a and 4b proteins of MERS-CoV may function against host innate immunity in a manner independent of host species and/or evolutionary clustering patterns.

Original languageEnglish
Article numbere1
JournalJournal of Veterinary Science
Volume20
Issue number2
DOIs
Publication statusPublished - 2019 Mar 1

Keywords

  • Middle East respiratory syndrome coronavirus
  • Molecular evolution
  • Phylogeny
  • Zoonoses

ASJC Scopus subject areas

  • veterinary(all)

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