Examining patterns of polypharmacy in bipolar disorder: Findings from the REAP-BD, Korea

Kiwon Kim, Hyunju Yang, Euihyeon Na, Hoseon Lee, Ok Jin Jang, Hyung Jun Yoon, Hong Seok Oh, Byung Joo Ham, Seon Cheol Park, Shih Ku Lin, Chay Hoon Tan, Naotaka Shinfuku, Yong Chon Park

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Based on Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar Disorder, this study tried to present prescription patterns in biopolar disorder (BD) and its associated clinical features. Based on the information obtained from the study with structured questions, the tendency of prescription pattern was studied and analyzed. Polypharmacy was predominant, including simple polypharmacy in 51.1% and complex polypharmacy in 34.2% of patients. Subjects associated with simple or complex polypharmacy were significantly younger, had higher inpatient settings, a larger portion of onset with manic episode, a shorter duration of untreated illness, a shorter duration of current episode, were more overweight, used less antidepressants and used more anxiolytics. These findings can suggest higher polypharmacy rate in more severe BD and highlight the necessity of monitoring the weight of subjects with polypharmacy.

Original languageEnglish
Pages (from-to)397-402
Number of pages6
JournalPsychiatry Investigation
Issue number5
Publication statusPublished - 2019 May


  • Antidepressant
  • Bipolar disorder
  • Inpatient
  • Polypharmacy

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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