Exchange living donor liver transplantation to overcome ABO incompatibility in adult patients

Shin Hwang, Sung Gyu Lee, Deok Bog Moon, Gi Won Song, Chul Soo Ahn, Ki Hun Kim, Tae Yong Ha, Dong Hwan Jung, Kwan Woo Kim, Nam Kyu Choi, Gil Chun Park, Young Dong Yu, Young Il Choi, Pyoung Jae Park, Hea Seon Ha

    Research output: Contribution to journalArticlepeer-review

    31 Citations (Scopus)

    Abstract

    ABO incompatibility is the most common cause of donor rejection during the initial screening of adult patients with end-stage liver disease for living donor liver transplantation (LDLT). A paired donor exchange program was initiated to cope with this problem without ABO-incompatible LDLT. We present our results from the first 6 years of this exchange adult LDLT program. Between July 2003 and June 2009, 1351 adult LDLT procedures, including 16 donor exchanges and 7 ABO-incompatible LDLT procedures, were performed at our institution. Initial donor-recipient ABO incompatibilities included 6 A to B incompatibilities, 6 B to A incompatibilities, 1 A to O incompatibility, 1 A+O (dual graft) to B incompatibility, 1 O to AB incompatibility, and 1 O to A incompatibility. Fourteen matches (87.5%) were ABO-incompatible, but 2 (12.5%) were initially ABO-compatible. All ABO-incompatible donors were directly related to their recipients, but 2 compatible donors were each undirected and unrelated directed. After donor reassignment through paired exchange (n = 7) or domino pairing (n - 1), the donor-recipient ABO status changed to A to A in 6, B to B in 6, O to O in 1, A to AB in 1, A+O to A in 1, and O to B in 1, and this made all matches ABO-identical (n = 13) or ABO-compatible (n = 3). Two pairs of LDLToperations were performed simultaneously on an elective basis in 12 and on an emergency basis in 4. All donors recovered uneventfully. Fifteen of the 16 recipients survived, but 1 died after 54 days. In conclusion, an exchange donor program for adult LDLT appears to be a feasible modality for overcoming donor-recipient ABO incompatibility.

    Original languageEnglish
    Pages (from-to)482-490
    Number of pages9
    JournalLiver Transplantation
    Volume16
    Issue number4
    DOIs
    Publication statusPublished - 2010 Apr

    ASJC Scopus subject areas

    • Surgery
    • Hepatology
    • Transplantation

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